科學論文選讀(一)
Research paper reading and discussion (I)
學期
106-1
學分
2
學分
當期課號
B530
永久課號
A7642
開課單位
分子醫學博士學位學程
授課教師
陳鴻震、蕭崇瑋、曾炳輝、黃奇英、陳念榮、蔡有光、黃彥華、金翠庭、翁雨蕙、俞震亞、李曉暉
校區
陽明
類別
必修
上課時間表
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 科學論文選讀(一) YL512 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | 課程介紹 |
| 第 2 週 | How to read a scientific paper |
| 第 3 週 | How to read a scientific paper |
| 第 4 週 | Lecture: Induced pluripotent stem cells (iPSCs): derivation and applications |
| 第 5 週 | Application of iPSC technology in drug screening (paper reading I) Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders. Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. |
| 第 6 週 | The basics for finding causative genes of human diseases |
| 第 7 週 | Finding the disease genes of simple diseases.(Paper reading II) Edvardson, S., Nicolae, C.M., Agrawal, P.B., Mignot, C., Payne, K., Prasad, A.N., Prasad, C., Sadler, L., Nava, C., Mullen, T.E. et al. (2017) Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood. Am J Hum Genet, 101, 267-273 |
| 第 8 週 | AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy (Introduction + Fig. 1, Fig. 2) (Paper reading III) Nature. 2016, 534, 553-557. |
| 第 9 週 | AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy (Fig. 3, Fig. 4 + Discussion) (Paper reading IV) Nature. 2016, 534, 553-557. |
| 第 10 週 | Introduction on innate immunity |
| 第 11 週 | Alarmin and infection (paper reading V) Immunity. Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection. 2015, 42(3):566-79. |
| 第 12 週 | Nutrient, Lymphoid cells and Barrier functions |
| 第 13 週 | (Paper reading VI) Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity. Science. 2014, 343, 432-437. |
| 第 14 週 | Drug discovery process in pharmaceutical company (Hit to Lead optimization) |
| 第 15 週 | (Paper reading VII) Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIA. Journal of Medicinal Chemistry. 2015, May |
| 第 16 週 | 演講(邀請未定) |
| 第 17 週 | How to write a research proposal |
| 第 18 週 |