科學論文選讀(二)
Research paper reading and discussion (II)
學期
106-2
學分
2
學分
當期課號
B672
永久課號
A7950
開課單位
分子醫學博士學位學程
授課教師
劉俊煌、蕭崇瑋、曾炳輝、黃奇英、陳念榮、蔡有光、黃彥華、蔡亭芬、蕭明熙、許翺麟
校區
陽明
類別
必修
上課時間表
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 科學論文選讀(二) YL512 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Metabolomics as the last OMICS; its potential and limitations in translational medicine蕭明熙 老師/黃奇英 老師 |
| 第 2 週 | From metabolic syndrome to T2DM and diabetic complications. 蕭明熙 老師/黃奇英 老師 |
| 第 3 週 | The application of metabolomics in human degenerative diseases.蕭明熙 老師/ 黃奇英 老師 |
| 第 4 週 | (Paper Reading I) Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes. Xu T. et al. Diabetes Care DOI: 10.2337/dc15-0658,2015蕭明熙 老師/黃奇英 老師 |
| 第 5 週 | (Paper Reading II) Microbial?Mammalian Cometabolites Dominate the Age-associated Urinary Metabolic Phenotype in Taiwanese and American Populations. Journal of Proteome Research. 12:3166?3180, 2013.蕭明熙 老師/黃奇英 老師 |
| 第 6 週 | Metabolic regulation and Immune responses 陳念榮 老師 |
| 第 7 週 | |
| 第 8 週 | (Paper Reading III) Major paper: Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Haghikia A. et al., Immunity 43, 817–829, 2015. References: Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain. Bhutia Y.D. and Ganapathy V. Immunity 43:629-631, 2015. Metabolic Regulation of Immune Responses. Ganeshan K. and Chawla A. Annu. Rev. Immunol. 32:609–634, 2014. 陳念榮 老師 |
| 第 9 週 | TCGA 黃彥華 老師 |
| 第 10 週 | A brief introduction on cancer genome 黃彥華 老師 |
| 第 11 週 | (Paper Reading IV) Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Cell 166, 755-765, 2016. 黃彥華 老師 |
| 第 12 週 | Introduction: The genetic regulation of aging 許?麟 老師 Major references: (1) Kenyon, C. (2010). The genetics of ageing. Nature, 464(7288): 504–512. Gems D. and Partridge L. (2013). Genetics of longevity in Model organism: debates and paradigm shifts. Annual Reviews of Physiology, 75: 621-644 |
| 第 13 週 | Molecular genetics of aging 許?麟 老師 (Paper Reading V) Riera CE. et al, TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. Cell. 22;157(5):1023-36, 2014. |
| 第 14 週 | Introduction: the hallmarks of aging 蔡亭芬 老師 Major references: (1) Lopez-Otin C., et al. The hallmarks of aging. Cell. 153(6):1194-217, 2013. (2) Zarrinpar A., et al. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab. 27(2):69-83, 2016. |
| 第 15 週 | Metabolism and aging (Paper Reading VI) Vermeij WP et al., Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature 537(7620): 427-431, 2016. 蔡亭芬 老師 |
| 第 16 週 | Application and Generationof Chimeric Antigen Receptor T (CAR-T) cells 劉俊煌 老師 |
| 第 17 週 | MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, Broady R, Levings MK. 劉俊煌 老師 |
| 第 18 週 |