結構生物資訊
Structural Bioinformatics
學期
107-1
學分
3
學分
當期課號
5702
永久課號
IBI5165
開課單位
生物資訊及系統生物研究所
授課教師
楊進木
類別
選修
上課時間表
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 結構生物資訊 BA301 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
概述
Studying the methods and concepts of computational drug design, such as docking, screening, lead optimization, machine learning methods and algorithms, scoring function, and databases.
先修科目
None
教學方式
Papers & public databases
評分方式
Homework (40%): Progress report or paper report Final project (40%) Examination: 20%
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to Structure Biology |
| 第 2 週 | Pairwise Sequence Alignment (BLAST Dynamic Programming) |
| 第 3 週 | Scoring matrix: BLOSUM-62 matrix |
| 第 4 週 | Multiple String Alignment (ClustalW and T-COFFEE) |
| 第 5 週 | Fundamentals of Protein Structures (Protein Data Bank)) |
| 第 6 週 | Molecular Visualization [Swiss PdbViewer) |
| 第 7 週 | Secondary structure prediction (DSSP, PHD: Neural Networks) |
| 第 8 週 | Structural Alignment (CE and 3D-BLAST) |
| 第 9 週 | Protein structure classification & databases (SCOP & CATH ) |
| 第 10 週 | Fold assignment & Fold Recognition (Support Vector Machine) |
| 第 11 週 | Homology Model (Swiss-Model and PS2) |
| 第 12 週 | Protein-Protein Interaction Prediction (Bayesian network ) |
| 第 13 週 | Protein-ligand docking (Genetic Algorithm) - 1 |
| 第 14 週 | Protein-ligand docking (Genetic Algorithm) - 2 |
| 第 15 週 | Compound similar search and clustering (Decision tree) |
| 第 16 週 | Structural Protein-Protein Interaction network |
| 第 17 週 | Metabolic pathways (KEGG) |
教科書
Papers: over one paper for each topic
Office Hours
- 地點
- 308 室: 博愛校區 生科實驗一館
- 時間
- 2CD
- 聯絡方式
- 56942