有機金屬於有機及高分子合成之應用
Orgarometallic for Organic and Polymer Synthesis
| 節 | 週二 |
|---|---|
2 09:00–09:50 | 有機金屬於有機及高分子合成之應用 SB203 3 節連堂 |
3 10:10–11:00 | |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
利用過渡金屬進行催化反應,生成新的碳碳鍵,是近年來最為強大的合成方法,在有機合成中已佔有舉足輕重的角色,本課程將會探討基本金屬的鍵結與配位性質,催化過程的反應機構,以及各種不同金屬的催化反應應用於各式有機合成之官能基的轉換以及高分子之合成。 Using transition-metal catalyzed reactions to proceed carbon-carbon formation is the most powerful tool and plays an important role in modern organic synthesis. This course will discuss the fundamentals of bonding and coordination properties, cataylic mechanisms, and a variety of transition metals applied in useful functional group transformations. Organometallics towards polymer synthesis will be also discussed.
大二有機化學 Before you take this course, please make sure you have passed sophomore organic chemistry.
板書及投影片教學 I will mostly use chalk and black board. Sildes are sometimes auxiliary.
評分方式:期中考(50%)、期末考(50%) Grading: Midterm (50%) and Final (50%)
- The Basic Chemistry of Organopalladium Compounds
- Classification of the Reactions Involving Pd (II) Compounds and Pd (0)
- Organometallic Reaction Mechanisms
- Oxidative Reactions with Pd (II) Compounds
- Catalytic Reactions with Pd (0) and Pd (II)
- Synthetic Applications of pi-Allyl Transition Metal Complexes
- Olefin Metathesis
- Palladium-Catalyzed C-H Activation Reactions
| 週次 | 主題 |
|---|---|
| 第 1 週 | Formalisms, Electron Counting and Bonding |
| 第 2 週 | Basic Organometallic Reaction Mechanisms |
| 第 3 週 | The Basic Chemistry of Organopalladium Compounds and Classification of the Reactions Involving Pd (II) Compounds and Pd (0) Complexes |
| 第 4 週 | Oxdiative Reactions with Pd (II) Compounds: Wacker Process |
| 第 5 週 | Oxdiative Reactions with Pd (II) Compounds: Wacker-type Reactions with other Nucleophilies |
| 第 6 週 | Catalytic Reactions with Pd (0) and Pd (II): Suzuki Coupling Reactions |
| 第 7 週 | Catalytic Reactions with Pd (0) and Pd (II): Stille Coupling Reactions |
| 第 8 週 | Catalytic Reactions with Pd (0) and Pd (II): Buchwald-Hartwig Aminations |
| 第 9 週 | Catalytic Reactions with Pd (0) and Pd (II): Heck Coupling Reactions and Sonogashira Coupling Reactions |
| 第 10 週 | Midterm Exam |
| 第 11 週 | Negishi Coupling Reactions and Nickel-Catalyzed Kumada-Corriu Coupling Reactions for Living Polycondensation |
| 第 12 週 | Palladium-Catalyzed Tsuji-Trost Allylations |
| 第 13 週 | Ullmann Coupling Reactions and Cobolt-Catalyzed Reactions |
| 第 14 週 | Fischer Carbene and Chromium-Catalyzed Reactions |
| 第 15 週 | Olefin Metathesis I |
| 第 16 週 | Olefin Metathesis II |
| 第 17 週 | Palladium Catalyzed C-H Activation Reactions |
| 第 18 週 | Final Exam |
Transition Metals in The Synthesis of Complex Organic Molecules, L. S. Hegedus, University Science Books, 1994 Palladium Reagents and Catalysts: Innovations in Organic Synthesis, Jiro Tsuji, Wiley, 1994
- 地點
- 田家炳大樓715室 My office is at Tin Ka-Ping building, room 715
- 時間
- 每週二 10:00-12:00 Discussion time with me: Every Tuesday morning 10:00-12:00
- 聯絡方式
- yjcheng@mail.nctu.edu.tw