固有無序蛋白質的結構、功能、與相關疾病
Structure, function, and diseases of intrinsically disordered proteins
學期
108-2
學分
1
學分
當期課號
B115
永久課號
B1845
開課單位
生化暨分子生物研究所
授課教師
黃介嶸
校區
陽明
類別
選修
上課時間表
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 固有無序蛋白質的結構、功能、與相關疾病 YC516 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Course Introduction |
| 第 2 週 | Protein structure hierarchy and protein functions |
| 第 3 週 | Tools for protein structure visualization and structural modeling |
| 第 4 週 | The intrinsically disordered proteins: a historical view |
| 第 5 週 | Biophysical and biochemical techniques for characterizing IDPs |
| 第 6 週 | Using NMR spectroscopy to characterize IDPs |
| 第 7 週 | Protein structure disorder and prediction: theory and software practice |
| 第 8 週 | Protein sequence complexity prediction |
| 第 9 週 | Midterm exam |
| 第 10 週 | Protein liquid-liquid phase separation |
| 第 11 週 | Structural disorder and diseases |
| 第 12 週 | Computational modeling for IDPs: restrained MD simulation |
| 第 13 週 | Conformational sampling of IDPS: flexible-meccano |
| 第 14 週 | Conformational selection using experimental restraints: Asteroids |
| 第 15 週 | Frontiers of IDP LLPS studies: signaling proteins |
| 第 16 週 | Frontiers of IDP LLPS studies: RNA binding proteins |
| 第 17 週 | Frontiers of IDP LLPS studies: centrosomes |
| 第 18 週 | Final exam |