基礎生物資訊統計學
Fundamental Statistical Methods in Bioinformatics
學期
109-1
學分
3
學分
當期課號
B859
永久課號
A8451
開課單位
生物資訊學程
授課教師
袁新盛
類別
必修
上課時間表
| 節 | 週四 |
|---|---|
2 09:00–09:50 | 基礎生物資訊統計學 3 節連堂 |
3 10:10–11:00 | |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | 09/16(Wed) Descriptive Statistics, Genomic Data Analysis (1)Introduction to statistics (2)Descriptive statistics (3)Fundamental of molecular biology (4)Genomic data analysis Lecturers:Dr. Chen-Hsiang Yeang |
| 第 2 週 | 09/17(Thu) Probability (1)Applications in statistical genetics (2)Combinatorial analysis (3)Axioms of probabilities (4)Conditional probability and independence (5)Random variable and distribution function Lecturers:Dr. Hsin-Chou Yang |
| 第 3 週 | 09/24(Thu) Discrete Distributions and Contingency Tables (1)An application in pharmacogenetic study (2)Discrete/continuous/mixed distributions (3)Joint/marginal/conditional distributions (4)Special discrete distributions (5)Introduction to contingency table Lecturers:Dr. Hsin-Chou Yang |
| 第 4 週 | Continuous Distributions, Expectations and Basic Statistics (1)Continuous random variable (2)Expectation (3)Basic statistics (4)Limit theorems (optional) Lecturers:Dr. Hsin-Chou Yang |
| 第 5 週 | Parameter Estimation and Confidence Interval (1)Unbiasedness (2)Point estimation (substitution principles, least square estimate, maximum likelihood estimate) (3)Interval estimation Lecturers:Dr. Shinsheng Yuan |
| 第 6 週 | Hypothesis Testing, P-value and False Discovery Rate (1)Hypothesis testing (2)Type I error and type II error (3)P-value (4)One-sample and two-sample z-tests (5)One-sample, two-sample, and paired t-tests (6)Bonferroni adjustment, false discovery rate, and q value Lecturers:Dr. Grace Shieh |
| 第 7 週 | Analysis of Categorical Data, Chisq and Multinomial (1)Incidence proportion and odds ratio (2)Two-sample test for binomial proportions (3)Contingency-table approach (4)Fisher’s exact test (5)McNemar’s test (6)Kappa statistic Lecturers:Dr. Hsuan-Yu Chen |
| 第 8 週 | Review Week (no class) |
| 第 9 週 | Midterm Exam |
| 第 10 週 | Correlation, Regression Analysis and ANOVA (1)Linear regression with one independent variable (2)Inference in regression analysis Lecturers:Dr. Grace Shieh (3)Diagnostic and remedial measures (4)Simultaneous inferences and other topics (5)Matrix approach to simple linear regression (6)Multiple linear regression (7)Building the regression model (8)Qualitative predictor variables (9)Analysis of variance |
| 第 11 週 | 11/25(Wed) Logistic Regression and Statistical Meta Analysis (1)Logistic regression (2)Meta analysis (effect size, precision, study weights, summary effect, heterogeneity, fixed-effect model, random-effect model, software) Lecturers:Dr. Shinsheng Yuan |
| 第 12 週 | 11/26(Thu) Survival Data Analysis (1)Mantel-Haenszel test (2)Survival and hazard functions (3)Kaplan Meier estimate (4)Log-rank test (5)Proportional-hazards model (6)Lung cancer study Lecturers:Dr. Hsuan-Yu Chen |
| 第 13 週 | 12/02(Wed) Clustering (1)Clustering by geometry (K-means, EM algorithm, hierarchical clustering, self- organizing map, principal component analysis, independent component analysis) (2)Clustering on graphs (Basic concepts, max flow – min cut, normal cuts, spectral clustering, and community detection) (3)Advanced topics (Chinese restaurant process and affinity propagation) Lecturers:Dr. Chen-Hsiang Yeang |
| 第 14 週 | 12/03(Thu) Classification (1)Binary classifications (Bayesian detection theory, naive Bayes and other generative models, non-parametric methods, Fisher linear discriminant, support vector machines and kernel techniques, artificial neural networks, and boosting) (2)Advanced topics in supervised learning (multi-class classification, feature selection, semi-supervised learning, active learning) Lecturers:Dr. Chen-Hsiang Yeang |
| 第 15 週 | 12/10(Thu) Nonparametric Statistics (I) (1)Bootstrap (2)One-sample sign test (3)One-sample Wilcoxon signed-rank test (4)Wilcoxon rank-sum test (Mann-Whitney U test) (5)Sign test for paired data (6)Wilcoxon signed-rank test for paired data Lecturers:Dr. Wei-Chung Liu |
| 第 16 週 | 12/17(Thu) Nonparametric Statistics (II) (1)Kruskal-Wallis test (2)Randomization/permutation test for two-way ANOVA (3)The product-moment correlation coefficient (4)Spearman rank correlation (5)Kendall’s coefficient of rank correlation Lecturers:Dr. Wei-Chung Liu |
| 第 17 週 | 12/24(Thu) Review Week (no class) |
| 第 18 週 | 12/31(Thu) Final Exam |