蛋白質物理生化學
Physical Biochemistry of Protein
學期
109-2
學分
3
學分
當期課號
5703
永久課號
IBT5566
開課單位
生物科技學系
授課教師
張家靖
校區
博愛
類別
選修
上課時間表
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 蛋白質物理生化學 BI308 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
概述
使學生對蛋白質之生物物理化學機制有所認知與徹底瞭解
先修科目
建議需具備普通物理與普通化學以上之修課經驗與能力
評分方式
出席率: 20% 作業部份:30% 期末報告: 50%
課程大綱
- 1. Introduction of protein 2. Elementary interactions in and around proteins 3. Secondary structure of polypeptide chains 4. Protein structures 5. Cooperation transitions in protein molecules 6. Prediction and design of protein structure. 7. Physical background of protein functions
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction of protein: Main functions of proteins |
| 第 2 週 | Elementary interactions in and around proteins a. Stereochemistry of L- amino acids b. Covalent bonds and angles between them c. Vibration, rotation around the covalent bonds d. Van de Waals interaction |
| 第 3 週 | Elementary interactions in and around proteins e. Influence of water environment f. Hydrogen bonds and their electrostatic origin g. Elements of thermodynamics h. Water-accessible surface of protein i. Influence of aqueous environment on electrostatic interactions |
| 第 4 週 | Secondary structure of polypeptide chains a. Elementary of statistical mechanics b. Temperature and probability of states with different energy c. The first order phase transitions |
| 第 5 週 | Secondary structure of polypeptide chains d. The theory of reaction rates e. Zipper model of alpha-helices f. beta-structure stability in water g. Properties of amino acid side chains |
| 第 6 週 | Protein structures a. Fibrous proteins and their functions b. Membrane proteins and their and their functions |
| 第 7 週 | Protein structures c. Globular proteins and their and their functions d. Intrinsic disorder proteins and their functions |
| 第 8 週 | Protein structures e. Classification of protein folds f. Selection rule of protein structure |
| 第 9 週 | Cooperation transitions in protein molecules a. Cooperative transitions b. Protein denaturation |
| 第 10 週 | Cooperation transitions in protein molecules c. Protein folding d. Protein aggregation |
| 第 11 週 | Prediction and design of protein structure a. Secondary structure prediction |
| 第 12 週 | Prediction and design of protein structure b. Tertiary structure prediction |
| 第 13 週 | Physical background of protein functions a. Structure function relationship of proteins |
| 第 14 週 | Physical background of protein functions b. Combination of elementary protein functions and flexibility of its structure |
| 第 15 週 | Special topics report, presentation and discussion |
| 第 16 週 | Special topics report, presentation and discussion |
| 第 17 週 | Special topics report, presentation and discussion |
| 第 18 週 | 期末考 |
教科書
Protein physics: A course of Lectures. Authors: Alexei V Finkelstein and Oleg B Ptitsyn Academic Press 2002
Office Hours
- 地點
- 生科實驗二館203室
- 時間
- 每星期二早上9:00~12:00
- 聯絡方式
- ext 31633