細胞訊息傳導與疾病
Signal transduction and diseases
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 細胞訊息傳導與疾病 YL735 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
綱要: I. 膜上受體 1.訊息傳導介紹 2. 受體 3. 離子通道的結構與功能 4. G蛋白偶合受體的分類與訊息傳遞路徑 5. 酵素連結受體的分類與訊息傳遞路徑 II.膜上受體與疾病 6.癌症 7. 老化 8. 自體免疫性 9. 神經性退化性 10.憂鬱症 11. 疼痛 Topics PART I – Introduction of membrane-bound receptors 1. Signal transduction: concept and overview 2. Receptors and First messenger 3. Ion channels: Structure and function 4. G-protein coupled receptors: structure, classification, and signaling pathways 5. Enzyme-coupled receptors: classification and signaling pathways PART II - Membrane-bound receptors and diseases: 6. Receptors and Cancer 7. Receptors and Aging 8. Receptors and Rheumatology 9. Receptors and Neurodegenerative Disorders 10. Receptors and Mood Disorders 11. Receptors and Pain
此課程主旨在介紹負責傳遞胞外多種訊息的膜上受體包括G蛋白偶合受體、酵素連結受體與離子通道,其調控胞內反應的分子機制與疾病的關連性。由於膜上受體功能上的缺失常造成許多疾病,因此此類型受體為極具潛力的藥物標的分子。至目前為止,超過半數的上市藥物都是藉由調控特定的膜上受體的訊息傳遞來治療疾病。課程內容包含兩部分:第一部分介紹 G蛋白偶合受體、酵素連結受體與離子通道的結構、功能與訊息傳遞路徑。第二部分將探討膜上受體與癌症、老化、自體免疫性、神經性退化性、憂鬱症、疼痛等疾病的關連性。除此之外,更包含近期科學在臨床藥理、醫學上重要研究與應用。藉由瞭解訊息傳遞分子機制配合目前臨床藥理、醫學上的研究的發展,讓學生了解膜上受體調控疾病的分子機轉,有助於學生在病理機制的基礎研究,臨床醫療發展與藥物開發與設計等應用。This course is to introduce signal transduction pathways through membrane-bound receptors that mediate many extracellular signals and regulate cellular responses. These membrane-bound receptors including G-protein-coupled receptors, enzyme-linked receptors and ion channels, are important for regulation of some diseases and serve as potential drug targets. At present, more than 50% of marketed drugs are targeted to membrane-bound receptors. The course contents include two parts: (I) Introduction of membrane-bound receptors: structures, functions and signaling pathways; (II) membrane-bound receptors and diseases: how receptors regulate diseases and what are molecular mechanisms. It also covers recent application of receptors in pharmacology and clinical medicine.
筆試60% + 上課表現10% +口頭及書面報告30%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Signal transduction: concept and overview Text book 1 Chapter 1, 1-17 |
| 第 2 週 | Receptors and First messenger Text book 1 Chapter 2, 21-35 |
| 第 3 週 | Ion channels: Structure and function Text book 1 Chapter 3, 37-73 |
| 第 4 週 | G-protein coupled receptors: structure and classification Text book 1 Chapter 3, 37-73 |
| 第 5 週 | G-protein coupled receptors: G protein signaling Text book 1 Chapter 4, 81-120 |
| 第 6 週 | Exam I |
| 第 7 週 | G-protein coupled receptors: cAMP signaling Text book 1 Chapters 5, 131-153; 9, 243-266 |
| 第 8 週 | G-protein coupled receptors: Phospholipid and calcium signaling Text book 1 Chapter 7, 185-239 |
| 第 9 週 | G-protein coupled receptors: G-protein-independent Text book 1 Chapters 7, 185-239; 9, 243-266 |
| 第 10 週 | Enzyme-coupled receptors: classification and signaling Text book Chapter 1, 1-17 |
| 第 11 週 | 運動會停課一次 |
| 第 12 週 | Enzyme-coupled receptors: Classification and Signaling Text book 1 Chapter 12, 315-362 |
| 第 13 週 | Exam II |
| 第 14 週 | Cell Cycle, Cell Death, Aging and Cancer Text book 1 Chapter 11, 297-311;14, 315-362; 20, 417-442; 23, 543-569 Text book 2 Chapter 11,12 599-632; 18, 735-758 |
| 第 15 週 | Signaling in Mood Disorders and Neurodegenerative Disorders Text book 2 Chapter 12,13, 377-447 |
| 第 16 週 | Pain as Channelopathy/ Rheumatology and Signal Transduction Text book 3 Chapter 3, 39-57 Text book 1 Chapter 16, 17, 483-538; Text book 2 Chapter 11, 357-377 |
| 第 17 週 | 彈性補充教學週 |
| 第 18 週 | 彈性補充教學週 |
1. Signal Transduction, 2009, 2nd edition by Gomerts, Kramer, and Tatham, Elsevier Inc. 2. Signal Transduction and human disease, 2003 by Finkel and Gutkind, A John Wiley & Sons, Inc 3. Pain Control, 2004, edited by Schaible HG