高等化學生物一

1 09/23 Thu. What is chemical biology? 2 09/27 Mon. Experiments relevant to understanding the origin of life 3 09/30 Thu. Guest Lecture: CRISPR technologies Kurt Mou 4 10/04 Mon. Nucleobase, nucleoside, and nucleic acid Paper discussion 5 10/07 Thu. Guest Lecture: CAR-T technologies Kurt Mou 6 10/11 Mon. National Day No class 7 10/14 Thu. Nucleic acid mimics + Quiz: nucleic acid structures [2] 8 10/18 Mon. DNA sequencing technologies Discussion 1 [3] 9 10/21 Thu. RNA, aptamers, ribozymes, and directed evolution 10 10/25 Mon. Classic directed evolution experiments and recent advances Discussion 2 [3] 11 10/29 Thu. Amino acids, peptides, and proteins 12 11/01 Mon. Ribosome and protein translation + Quiz: amino acid structures [2] 13 11/04 Thu. Protein degradation and misfolding Discussion 3 [3] 14 11/08 Mon. Mid-term week No class 15 11/11 Thu. MID-TERM EXAM [4] No class 16 11/15 Mon. Incorporate noncanonical amino acids into proteins 17 11/18 Thu. Carbohydrates and lipids Discussion 4 [3] 18 11/22 Mon. Carbohydrates and lipids 19 11/25 Thu. Secondary metabolites 1 20 11/29 Mon. Secondary metabolites 2 21 12/02 Thu. Please attend KT Wang Lectures (TBD) [5] No class 22 12/06 Mon. Bioconjugation chemistry Discussion 5 [3] 23 12/09 Thu. Fluorescent dyes and proteins 25 12/13 Mon. Super-resolution fluorescence imaging Electron microscopy 26 12/16 Thu. Analytical technologies for biomaterials Discussion 6 [3] 27 12/20 Mon. Student presentation 1 [6] 28 12/23 Thu. Student presentation 2 [6] 29 12/27 Mon. Student presentation 3 [6] 30 12/30 Thu. TBD 32 01/03 Mon. Final week No class 16 01/06 Thu. FINAL EXAM [4] Notes: [1] PowerPoint slides and assigned reading materials will be uploaded to CEIBA (ceiba.ntu.edu.tw) course website. [2] There will be a short quiz (no more than 5 questions) after each class. Quizzes on 10/14 and 11/11 will ask you the chemical structures of nucleic acids and amino acids, respectively. [3] Paper discussion sessions will be held about every 2 weeks. You should read the assigned papers before the discussion sessions. [4] You will be allowed to write notes on a piece of A4 paper and bring it to the mid-term and final exams. [5] KT Wang Bioorganic Chemistry Lecture (王光燦生物有機化學講座) usually features great talks; content of the lecture will be included in the final exam. The exact date has not been announced; we will move our class around for the lecture. [6] Student presentations have a strict 5 min. limit. You should a) make and present a 1-slide infographic and b) provide a short quiz about your presentation. I will select a few questions to include in the final exam. Check out the following link and examples. http://www.compoundchem.com https://www.foodprocessing.com/articles/2014/infographic-chemistry-of-food/ https://www.distillerytrail.com/blog/chemistry-inside-tiny-champagne-bubbles-infographic/

Everyone enrolled in this class should have taken undergraduate level biochemistry. Some background information from basic biochemistry will be provided in the lectures. Undergraduate students can enroll only if they have already taken (and passed) biochemistry.

English (lectures, exams, and student presentations shall all be given in English) Students must also answer exam questions in English

Midterm exam 35%; Final exam 35%; Presentation 15%; In-class quizzes 10%; Discussion 5%