核醫藥物與磁振造影對比劑合成
Synthesis of Radiopharmaceuticals and MR Contrast Agents
學期
110-1
學分
2
學分
當期課號
A979
永久課號
A3141
開課單位
生物醫學影像暨放射科學系
授課教師
陳傳霖
校區
陽明
類別
選修
上課時間表
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 核醫藥物與磁振造影對比劑合成 YB134 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
概述
放射性鹵素標誌技術, 碳-11標誌技術, 金屬螯合基, bioconjugation chemistry, 放射性鎝及放射性金屬核種標誌技術Radiohalogenation, C-11 radiolabeling, chelators, bioconjugation chemistry, Tc-99m and radiometal labeling
教學方式
認識核醫藥物的特性及相關標誌技術與原理To study the characteristics of radiopharmaceuticals and related radiolabeling and synthetic methodologies
評分方式
mid-term exam 40% Final exam 40% report 20%
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction:Molecular imaging probesIntroduction: |
| 第 2 週 | HolidayMolecular imaging probes |
| 第 3 週 | Fluorine-18 Labeling of Small MoleculesGeneral Fluorine-18 Labeling Methods |
| 第 4 週 | Fluorine-18 Labeling of of Peptides and ProteinsFluorine-18 Labeling of Small Molecules |
| 第 5 週 | Advanced Fluorine-18 Labeling MethodsFluorine-18 Labeling of of Peptides and Proteins |
| 第 6 週 | General radiohalogen Labeling Methods (except F-18)Advanced Fluorine-18 Labeling Methods |
| 第 7 週 | General Carbon-11 Labeling ChemistryGeneral radiohalogen Labeling Methods (except F-18) |
| 第 8 週 | Carbon-11 Labeling Chemistry Based upon [11C]Methyl IodideGeneral Carbon-11 Labeling Chemistry |
| 第 9 週 | Midterm exam |
| 第 10 週 | Basic concept of coordination Chemistry and BioconjugationCarbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide |
| 第 11 週 | Basic 99mTechnetium ChemistryBasic concept of coordination Chemistry and Bioconjugation |
| 第 12 週 | Organometallic Technetium Complexes for Imaging Basic 99mTechnetium Chemistry |
| 第 13 週 | Copper radiopharmaceuticals Organometallic Technetium Complexes for Imaging |
| 第 14 週 | other Metallic Radionuclides for PET Imaging (I)Copper radiopharmaceuticals |
| 第 15 週 | other Metallic Radionuclides for PET Imaging (II)Metal Radionuclides for PET Imaging (I) |
| 第 16 週 | Final exam Metal Radionuclides for PET Imaging (II) |
| 第 17 週 | report 1Metal Radionuclides for PET Imaging (III) |
| 第 18 週 | report 2Final exam |
教科書
contrast agents II and III Springer; Softcover reprint of hardcover 1st ed. 2002版 (4 12 月 2010) and Springer; 第2005版 (10 2 月 2005)