生物技術於醫學之應用
Biotechnology in Medicine
| 節 | 週二 |
|---|---|
5 13:20–14:10 | 生物技術於醫學之應用 YT103 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
生物技術產業與法規 基因分析:報告基因、陣列與新測序技術 使用原核生物進行基因表達 使用真核生物製造重組蛋白質 植物生物技術 核酸治療藥物 治療用抗體 疫苗 蛋白質體學 微生物群 實驗動物模型 新藥研發 Biotechnology industry and regulation Gene analysis: Reporter, array, and new sequencing technology Manipulation of gene expression in prokaryotes Heterologous protein production in eukaryotic cells Plants biotechnology Nucleic acid therapeutics Antibody therapeutics Vaccines Proteomics Microbiota Experimental animal models Research and development of new drugs
本課程包括生物技術產業的一般介紹以及生物技術在醫學中的原理和應用的示例。講座內容包括在原核生物和真核生物中的基因表達操縱、高通量微陣列、核?酸測序和蛋白質體學技術,在學術和生物技術產業中的研究與開發。課堂上還將提供抗體、核酸和其他治療劑、疫苗和微生物群的開發和應用示例。完成本課程後,學生應能夠: 1.展示對生物醫學研究和生物技術行業中使用的一般方法和先進技術的原理和應用的常識 2.展示基因組學、轉錄組學和蛋白質組學的基本知識及其在生物醫學研究中的應用 3.證明對抗體和核酸療法在臨床環境中的基本知識和應用 4.展示在不同宿主系統中表達重組蛋白的實用知識 5.展示對抗體和核酸療法的生產和應用方面的工作知識 6.展示對疫苗開發、生產和應用方面的工作知識 This course consists a general introduction of biotechnology industry and examples of the principle and applications of biotechnology in medicine. Lectures include the manipulation of gene expression in prokaryotes and eukaryotes, and high-throughput microarray, nucleotide sequencing, and proteomics technologies for research and development in academic and biotechnology industry settings. Examples of the development and applications of antibody, nucleic acid, and other therapeutics, vaccines, and microbiota will also be provided in the classroom. After completion of this course, the students should be able to: 1.demonstrate a general knowledge of the principle and applications of general methodologies and advanced technologies used in biomedical research and biotechnology industries 2.demonstrate a fundamental knowledge of genomics, transcriptomics, and proteomics and their applications in biomedical research 3.demonstrate a basic knowledge and applications of antibody, and nucleic acid therapeutics in clinical settings 4.demonstrate a working knowledge of expression of recombinant proteins in different host systems 5.demonstrate a working knowledge of production and applications of antibody and nucleic acid therapeutics 6.demonstrate a working knowledge of the development, production, and applications of vaccines
隨堂測驗、考試與提交的報告進行評分Quizzes, examinations, and reports
| 週次 | 主題 |
|---|---|
| 第 1 週 | Biotechnology industry and regulation |
| 第 2 週 | Manipulation of gene expression in prokaryotes |
| 第 3 週 | Gene analysis: reporter, array and new sequencing technology |
| 第 4 週 | Nucleic acids as the therapeutic agents |
| 第 5 週 | Heterologous protein production in eukaryotic cells |
| 第 6 週 | Experimental Animal Model |
| 第 7 週 | 期中考 (範圍: 堂次1-6) |
| 第 8 週 | 民族掃墓節(放假一天) |
| 第 9 週 | Microbiota *Proteomics-Principle and applications 吳韋訥(線上上課) |
| 第 10 週 | Plant biotechnology *Vaccine 黃尉倫(線上上課) |
| 第 11 週 | Antibody therapeutics |
| 第 12 週 | 新藥研發 |
| 第 13 週 | 期末考 (範圍: 堂次7-12) |
| 第 14 週 | |
| 第 15 週 | |
| 第 16 週 | |
| 第 17 週 | |
| 第 18 週 |
參考用的教科書: Molecular Biotechnology: Principles and Application of Recombinant DNA. B. R. Glick and C. L. Patten (5th edition) 2017