神經膠細胞之功能與疾病
Functions and Diseases of Neuroglia
| 節 | 週三 |
|---|---|
5 13:20–14:10 | 神經膠細胞之功能與疾病 YL837 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
1. 分別介紹星狀膠細胞、、微膠細胞、及寡突膠細胞的發育與基本生理功能 2.星狀膠細胞之多元性、形成血腦屏障及突觸三分體、及膠細胞傳導等特性 3. 微膠細胞於神經免疫及神經退化之角色 4. 寡突膠細胞與去髓鞘化疾病 5. 膠細胞癌症1. Development and basic physiological functions of neuroglia 2. Heterogeneity, formation of BBB and tripartite synapses of astrocytes 3. Microglia in CNS immunity and neurodegeneration 4. Oligodendrocytes in demyelinating diseases 5. Cancers of neuroglia
本課程為介紹神經膠細胞: 星狀膠細胞、微膠細胞、及寡突膠細胞,之基本及最前沿之細胞生物及生理特性,以及在中樞神經系統疾病之角色。This course will introduce the fundamental as well as cutting edge knowledge of the cell biology, development, and physiological functions of neuroglia, including astrocyte, microglia and oligodendrocytes. CNS diseases involving dysfunction or dysregulation of glial functions will be discussed.
出席成績60%, 期末報告40%Attendance 60%, Final Report 40%
| 週次 | 主題 |
|---|---|
| 第 1 週 | 校慶活動日(停課一日、不停班) |
| 第 2 週 | Introduction-Neuroglia Overview |
| 第 3 週 | Electrical Properties of Astrocytes |
| 第 4 週 | Astrocytes- Neurotransmitter homeostasis at tripartite synapses |
| 第 5 週 | Astrocytes- Blood-Brain Barrier and Neurovascular Unit |
| 第 6 週 | Astrocyte plasticity and metabolismAstrocyte calcium signaling |
| 第 7 週 | Gliotransmision: a layer of information processing |
| 第 8 週 | 校際活動週(放假一天) |
| 第 9 週 | Astrocyte calcium signaling ATP in astrocyte-neuron interaction |
| 第 10 週 | Discussion (midterm discussion on astrocytes)Microglia development and in CNS Immunity |
| 第 11 週 | Microglia development and in CNS ImmunityAstrocyte plasticity and metabolism |
| 第 12 週 | Glia in Neurodegenerative Diseases |
| 第 13 週 | Cancers of neuroglia |
| 第 14 週 | Oligodendrocytes- Development and Functions |
| 第 15 週 | Demyelination and remyelination |
| 第 16 週 | Physiology of Oligodendrocyte Progenitor Cells (OPCs)/NG2 Cells |
| 第 17 週 | Conference meeting (3/25-27 JACBS Conference)Conference meeting (於3/25-27參加生醫年會) |
| 第 18 週 | Final Report (Online)Final Report (線上報告) |
Neuroglia, Edited by Kettenmann and Ransom, 3rd ed., Oxford University Press 各單元指定閱讀之研究論文和文獻回顧