神經退化致病機轉
Molecular Mechanisms Underlying Neurodgeneration
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 神經退化致病機轉 YL837 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
本課程一開始先介紹常見於不同神經退化性疾病中的共通下游致病機轉,包括氧化壓力與自由基所造成之傷害。接著介紹下列各種慢性神經退化性疾病:巴金森氏症、漢丁頓舞蹈症與其他tri-nucleotide repeat expansion遺傳性疾病、肌萎縮側索硬化症(患者俗稱漸凍人)與額顳葉失智症、阿玆海默症與唐氏症等。最後介紹急性中樞神經損傷如缺血性及出血性腦中風等。 This course is composed of three parts. The first part is the introduction of downstream pathogenic mechanisms common to various neurodegenerative disorders and acute CNS injury, particularly focusing on oxidative damages. We than begin the introduction of chronic neurodegenerative disorders, such as Parkinson’s disease, Huntington’s disease and other tri-nucleotide repeat-expansion disorders, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as Alzheimer’s disease and Down syndrome. This course ends with the introduction to acute CNS disorders, include cerebral ischemia (focal and global) and hemorrhagic stroke.
本課程主要為腦科學研究所學生開設,他所學生對神經系統相關疾病有興趣者亦歡迎選修或旁聽。教學目標在於介紹慢性神經退化性疾病與急性神經系統損傷的致病分子機轉,並據以介紹可能的神經保護機轉以及未來對這些神經性疾病的治療方向。有先修過基礎生物學或基礎分子細胞生物學為佳,但非必需。 This course is designed for graduate students in the Institute of Brain Science; students from other institutions with strong interests in these topics are also welcome. The main objective of this course is to provide with students the background knowledge concerning the molecular mechanisms underlying neurodegeneration during the progression of chronic neurodegenerative diseases as well as acute injury in central nervous system (CNS). Furthermore, we will discuss potential protective strategies for future development of therapeutic regimen against neurodegeneration. It would be helpful if the students have previously taken the courses of basic biology or molecular/cellular biology. However, this is not mandatory.
教學方式以授課教師於課堂講授為主,輔以小組問答討論;若因新冠疫情嚴峻,亦可能視情況改以EverCam軟體預錄課程,同學至NewE3平台觀看錄製好的課程檔案。本選修課程並無助教,學生若對課程有問題可以直接以電郵與授課教師聯絡,或於Office Hours (每週五上午10:00-12:00)。 This course mainly involves in-class teaching, coupled with group discussion; in case of Covid-19 pandemic, the instructor will record the presentations with EverCam and the students may view the media files on NewE3. There is no teaching assistant for this elective course. Students who have questions regarding the contents of this course may contact the instructor via e-mail or directly visit the instructor during Friday morning 10:00-12:00.
依出席率與隨堂抽問(共20%)以及兩次口頭報告(各40%)考評其學習成效。 Evaluation for the performance of students is based on attendance and pop quiz (20% total) and two oral presentations (40% each).
| 週次 | 主題 |
|---|---|
| 第 1 週 | Course introduction |
| 第 2 週 | Oxidative alterations in neurodegenerative diseases |
| 第 3 週 | Parkinson's disease - introduction and pathological mechanisms |
| 第 4 週 | Parkinson's disease - genetic factors of familial PD |
| 第 5 週 | RNA-mediated neurodegeneration in repeat expansion disorders |
| 第 6 週 | Toxic mechanisms of polyQ diseases (Huntington’s disease and spinocerebellar ataxia) and protective strategies |
| 第 7 週 | Amyotrophic lateral sclerosis (ALS) |
| 第 8 週 | Mid-term oral presentation |
| 第 9 週 | Frontotemporal lobar dementia (FTD) |
| 第 10 週 | Alzheimer's disease - introduction and genetic factors |
| 第 11 週 | Alzheimer's disease - ApoE, Abeta clearance, imaging, and detection |
| 第 12 週 | Alzheimer's disease - experimental models and therapy |
| 第 13 週 | Down syndrome |
| 第 14 週 | Stroke - pathological mechanisms and experimental models |
| 第 15 週 | Stroke - experimental models and therapeutic strategies |
| 第 16 週 | Final oral presentation |
| 第 17 週 | Free discussion |
| 第 18 週 | Free discussion |
由授課教師根據相關的綜論文獻準備簡報投影片,無指定參考書。 For each topic, the instructor prepares the PowerPoint slides based on the relevant reviews and original articles. No textbooks are used in this course.
- 地點
- 陽明校區圖書資訊大樓851室 Rm# 851, Building of Library and Information, Yang-Ming Campus, Taipei
- 時間
- 每週五上10點至中午12點 Friday 10:00-12:00
- 聯絡方式
- Tel: 02-28267386 校內分機: 67386 E-mail: diyang@nycu.edu.tw