高等細胞生物學
Advanced Cell Biology
| 節 | 週二 |
|---|---|
3 10:10–11:00 | 高等細胞生物學 YB134 2 節連堂 |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
細胞生物學是了解原核及真核生物的構造、生長、行為等等重要的學科。而高等細胞生物學則針對細胞的生理,以分子生物的角度來詳細介紹為何單純的細胞會有這麼多複雜的行為。課程將從細胞的膜、胞器、分子傳遞、訊息傳導、細胞週期與死亡、細胞微結構與外界環境之交互作用、幹細胞、以及癌症發生等等來逐一介紹。除了指定之教科書外、也會介紹最新的研究論文,以及未來的趨勢。修課同學也必須選讀一篇一年內發表在細胞生物領域相關期刊之論文,並做口頭報告。This course is focused on the molecular events of cells to elucidate the complicate physiological phenomena, including structures, proliferation and behaviors. It will cover but not limit to the cell membrane, organelles, intracellular molecular transport, singal transduction, cell cycle and death, cytoskeletons, microenvironmental interaction, stem cell biology, and etiology of cancer cells. In addition to the indicated textbook, the most update papers in cell biology field will be discussed to understand the future tendency of research. Moreover, students are assigned to oral present two contemporary reports related the cell biological research.
建議先修細胞生物學
介紹分子層次的交互作用在細胞與次細胞的行為、生長、基因表達、通訊、結構、微環境、分化等之影響To introduce the effects of molecular interaction on cellular and subcellular behaviors, structures, proliferation, differentiation, signaling communication, gene expression, and microevironmental regulation.
a. 期中考與期末考: 各30% b. 論文報告 (兩次) : 各 10% c. 出席率 : 20% a. Midterm and Final exanminations: 30% each b. Paper presentations (twice) : 10% each c. Attendance : 20%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Course Introduction and Basic Life Science in Eukaryotic Cells |
| 第 2 週 | The Cell Membrane – structure and transport of small molecules) |
| 第 3 週 | Intracellular compartments and protein targeting |
| 第 4 週 | Transport Across Membranes: Overcoming the Permeability Barrier |
| 第 5 週 | Intracellular vesicular traffic – Role of Golgi appartus, endocytosis and exocytosis |
| 第 6 週 | Mitochondria |
| 第 7 週 | Physical/mechanical effects of cells – junctions and adhesions and Extracellular Matrix |
| 第 8 週 | Mid-term examination Current Topics |
| 第 9 週 | The Cytoskeletons |
| 第 10 週 | Signal transductions (I) |
| 第 11 週 | Signal transductions (II) |
| 第 12 週 | The Cell Growth: Cell cycle, Apoptosis and Autophagy |
| 第 13 週 | Cancer Cells |
| 第 14 週 | Immune Cells |
| 第 15 週 | Stem cell biology |
| 第 16 週 | Final examination |
| 第 17 週 | Current Topic I |
| 第 18 週 | Current Topic II |
a. Molecular Biology The Cell, 4th Ed. 2002, Alberts, B et al., Garland Science, USA b. Contemporary papers.