結構生物學(一)
Structural Biology(I)
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 結構生物學(一) YK101 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
This course is designed to introduce the structure biology. Since 2000-2015, after human genome project, USA once again executed a huge scientific project. Now it is “Structure Genomics”. The project established several huge structure genomic center such as Northeast Structure Genomic Center (NESG). Their duty is very simple; i.e., trying to solve the protein structures as more as we can, no matter what their functions are. They believe that when we get lots of the structures, we can learn the function towards structures. No doubt, after 15 years’ efforts now we have at least 100,000 structures. Until now, each year there are still at least 10,000 solved structures published on protein data bank. The big data of “Structure of Macromolecules” has formed. Towards these data, now we can understand the detailed mechanism of macromolecules, such as biomolecular interactions, interactome, enzymatic catalysis, and medicine (protein drugs).
The aim of this class is to give students the basic concept of structure biology, including primary to quaternary structures and the methodology of this field. Only understanding the basic and tools, students are able to know how to do the structure research. We believe that understanding the structure and then designing what we need (protein engineering, drug design) is still one of the most important research fields of the next 50 years.
reports, 50%; exam, 50%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Basics of protein structure (textbook 2, chapter 2) |
| 第 2 週 | Secondary, Tertiary, and Quaternary Structure (textbook 3, chapter 6) |
| 第 3 週 | Classification of protein structure (textbook 1, chapter 3 & textbook 3, chapter 6) |
| 第 4 週 | Methods of Structural determination (textbook 1, chapter 3) |
| 第 5 週 | Principles of Structure Prediction I (textbook 1, chapter 3) |
| 第 6 週 | Principles of Structure Prediction II (textbook 1, chapter 3) |
| 第 7 週 | Methods of Structure Prediction (textbook 1, chapter 3) |
| 第 8 週 | Energetics and Protein Stability (textbook 1, chapter 4) |
| 第 9 週 | Protein Data Bank and Pymol tutorial (textbook 1, chapter 3) |
| 第 10 週 | Protein dynamics and folding (textbook 1, chapter 5) |
| 第 11 週 | Intrinsically disordered proteins I (textbook 1, chapter 6) |
| 第 12 週 | Intrinsically disordered proteins II (textbook 1, chapter 6) |
| 第 13 週 | Structure of biological membranes (textbook 1, Chapter 7) |
| 第 14 週 | Membrane protein structure (textbook 1, Chapter 7) |
| 第 15 週 | Protein-membrane interaction (textbook 1, Chapter 7) |
| 第 16 週 | G protein-coupled receptors (textbook 1, Chapter 7) |
| 第 17 週 | 補充教學 Methods of Structural determination (textbook 1, chapter 3) |
| 第 18 週 | 補充教學 Energetics and Protein Stability (textbook 1, chapter 4) |
1. Introduction to Proteins: Structure, Function, and Motion (2011) Amit Kessel & Nir Ben-Tal 2. Textbook of Structural Biology (2009) Anders Liljas et al. 3. Biochemistry (Reginald H. Garrett & Charles M. Grisham)