代謝工程應用於再生能源與材料

Metabolic Engineering for renewable fuel and chemicals

學期

111-1

學分

3 學分

當期課號

430019

永久課號

BTBT30004

開課單位

分子醫學與生物工程研究所

授課教師

蘭宜錚

校區

博愛

類別

選修

上課時間表

節	週一
7 15:30–16:20	代謝工程應用於再生能源與材料 BI311 3 節連堂
8 16:30–17:20
9 17:30–18:20

* 根據陽明交大上課時間表所列

概述

代謝工程廣泛的定義為:以基因工程技術來改變細胞內的代謝途徑以及其調控功能而導致所想要的細胞表型。代謝工程現是廣泛使用的技術來提高菌體生物量或代謝物產量例如生質能源、高分子單體、藥物起始物等。本課程目的是讓學生認是以及熟悉代謝工程學以及它在生化產業的應用。本課程強調生產生質化學品的生化反應與途徑。 Metabolic Engineering is broadly defined as using genetic tools to modify the cellular metabolic pathways and regulations to achieve a particular phenotype. Such phenotype typically includes the optimization of biomass formation and/or production of valuable compounds including those that form biofuels, biochemicals, drug precursors, etc. The goal of this course is to familiarize students with the field of metabolic engineering and its application in current biochemical industry. This course focuses on the biochemistry and metabolic pathways for the production of useful biochemicals.

先修科目

先修科目或先備能力:生物化學(二)或相關生化(代謝)基礎. Biochemistry II or general knowledge of metabolism is highly recommended. This course is taught in English

教學方式

Slides will be either posted on E3 or printed out

評分方式

Exam: 50% Presentation: 40% Participation: 10%

週次計畫

週次	主題
第 1 週	Course Introduction
第 2 週	Central metabolism - Glycolysis, sugar metabolism, and TCA cycle
第 3 週	Central metabolism - Glycolysis, sugar metabolism, and TCA cycle
第 4 週	Photosynthesis and CO2 fixation
第 5 週	Fermentation
第 6 週	Biofuel
第 7 週	Chemicals: plastic monomers part I
第 8 週	Chemicals: plastic monomers part II
第 9 週	Chemicals & natural products: pharmaceuticals and intermediates
第 10 週	Non-traditional biological feedstock
第 11 週	Synthetic pathway designs: Rational designs
第 12 週	Synthetic pathway designs: directed evolutions
第 13 週	Exams
第 14 週	Current special topics
第 15 週	Current special topics
第 16 週	Presentations
第 17 週	Presentations
第 18 週	Presentations

教科書

Lecture slides & recent journal publications

Office Hours

地點: EF458
時間: To be announced
聯絡方式: Email: ethanilan@nctu.edu.tw Campus extension: 59719