神經發育與幹細胞
Neural Development and Stem Cells
| 節 | 週五 |
|---|---|
3 10:10–11:00 | 神經發育與幹細胞 YL837 2 節連堂 |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
神經系統當今瞭解神經細胞如何生成及神經幹細胞如何再生仍是一項挑戰,目前已知整個過程必須經由極為複雜的途徑。在人類以及其他的哺乳類動物中,神經幹細胞與神經元之型態及運動能力在不同階段會產生複雜變化,這個過程牽涉到至少數百個基因,以及結構上戲劇性的改變。在這個過程中若出任何差錯,將會對腦部發育產生重大影響,並造成新生兒腦部缺陷。本課程希望能夠讓同學瞭解神經發育這段複雜過程的控制機制,並?發對這方面研究的興趣。Today, to understand the mechanisms of how neuronal cells are born and how neural stem cells regenerate themselves in the nervous system during embryonic development is a key challenge in neural stem cell research. The pathway by which neuronal cells are born is itself proving to be complex. In human, as well as other mammals, cortical neurons are generated by the neural stem cells, which exhibit a characteristic yet mysterious pattern of morphological changes. To date, only a few genes are identified to control and regulate the progression of this neurogenesis pathway. This course is aimed to give students an overview of this complex process and to stimulate the interest in this research field.
期中考40%,期末考40%,開書考(可帶上課講義) 課堂表現20%Midterm Exam 40% (open book), Final Exam 40% (open book), Attendance 20%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction: An Overview of Neural Development |
| 第 2 週 | Neural Induction |
| 第 3 週 | Polarity and Segmentation |
| 第 4 週 | Genesis and Migration of Neurons and Glia |
| 第 5 週 | Genesis and Migration of Neurons and Glia |
| 第 6 週 | Cell Fate Determination and Differentiation |
| 第 7 週 | Axon Growth and Guidance |
| 第 8 週 | Midterm Exam |
| 第 9 週 | Axonal Target Selection |
| 第 10 週 | Naturally-Occurring Neuron Death |
| 第 11 週 | Synapse Formation and Function |
| 第 12 週 | Refinement of Synaptic Connections |
| 第 13 週 | Refinement of Synaptic Connections |
| 第 14 週 | Behavioral Development |
| 第 15 週 | Behavioral Development |
| 第 16 週 | Final Exam |
| 第 17 週 | 彈性多元教學 |
| 第 18 週 | 彈性多元教學 |
Development of the Nervous System, 3rd Edition. Sanes, Reh, & Harris, 01 Apr 2011, Academic Press, ISBN: 9780123745392