癌症細胞生物學
Cancer Cell Biology
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 癌症細胞生物學 YT103 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
課程概述: 癌症細胞生物學是一門研究所課程,將向學生介紹腫瘤學和細胞生物學的基本原理,包括癌症發生、發展和治療的細胞和分子過程。本課著重於基因、表觀基因、細胞和環境等因素在癌症發生與進展中的關聯性,內容涵蓋了從致癌基因和抑癌基因到癌症代謝和腫瘤微環境等各種主題。此課程還將介紹應用在癌症研究中的分子生物學、細胞基礎技術和動物模型。通過課堂講座、案例研究和問題導向學習(PBL)報告,學生將全面理解癌症細胞生物學,為他們未來在腫瘤學的研究或臨床實踐做好準備。 Course Overview: Cancer Cell Biology is a graduate course that will expose students to the fundamental principles of oncology and cell biology, focusing on the cellular and molecular processes that govern cancer onset, progression, and treatment. This course emphasizes the genetic, epigenetic, cellular, and environmental factors in the development and progression of cancer, incorporating a wide variety of topics ranging from oncogenes and tumor suppressor genes to cancer metabolism and tumor microenvironment. This course will also introduce the application of molecular biology, cell-based techniques, and animal models in cancer research. Through lectures, case studies, and problem-based learning (PBL) reports, students will gain a comprehensive understanding of cancer biology, helping to prepare them for future research or clinical practice in oncology. 課程目標: 1. 介紹癌症細胞生物學的基本概念和關鍵過程 2. 使學生熟悉癌細胞的生物學特性 3. 提高學生對癌症檢測、診斷和治療選項的理解 4. 通過問題導向學習報告,獲得癌症研究方法的實踐技能 5. 培養學生的科學演講和寫作技能 Course Objectives: 1. Introduction to fundamental concepts and key processes in cancer cell biology 2. Familiarization with the biological hallmarks of cancer cells 3. Enhancement of students' understanding of cancer detection, diagnosis, and treatment options 4. Acquisition of practical skills in cancer research methods through problem-based learning (PBL) reports 5. Fostering of students' scientific speaking and writing skills
選修此課程並無特定的先修課程要求,但若具備生物學、遺傳學和細胞生物學等學科的基本認識,將有助於本課程的理解。具備科學閱讀、寫作和批判性思考的能力亦有助成功完成課程。 No specific prerequisites are required for this course. However, a basic understanding of biology, genetics, and cell biology would be beneficial. Proficiency in scientific reading, writing, and critical thinking skills are also important for successful completion of the course.
所有參考書目皆可透過陽明交通大學圖書館線上取得。 All reference materials can be obtained online through the NYCU Library.
出缺席及課堂參與度20% 口頭PBL分組報告 40% 期中末寫作報告 40% Attendance and class participation: 20% Oral problem-based learning (PBL) presentation: 40% Midterm and final writing reports: 40%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction Epidemiology and Etiology of Cancer |
| 第 2 週 | Oncogenes and Aberrant Signal Transduction |
| 第 3 週 | Tumor Suppressor Genes and Cell Fate Control |
| 第 4 週 | Cancer Genomics and Genome Instability |
| 第 5 週 | Holiday |
| 第 6 週 | Cancer Epigenomics |
| 第 7 週 | Cell Death and Immortality of Cancer Cells Cancer metabolism |
| 第 8 週 | Midterm Written Report |
| 第 9 週 | Cancer Stemness Tumor Microenvironment |
| 第 10 週 | Hypoxia and Angiogenesis Invasion and Metastasis |
| 第 11 週 | Tumor Immunology The Hallmarks of Cancer |
| 第 12 週 | Detecting and Diagnosing Cancer Cancer Therapy and Vaccines |
| 第 13 週 | PBL Report (I) Application of Molecular Biology Techniques in Cancer Research |
| 第 14 週 | PBL Report (II) Application of Cell-based Techniques in Cancer Research |
| 第 15 週 | PBL Report (III) Application of Animal Models in Cancer Research |
| 第 16 週 | Final Written Report |
1. Cancer Biology: How Science Works by Carsten Carlberg and Eunike Velleuer. Jul 5, 2021 (Springer) 2. Holland-Frei Cancer Medicine (The Holland-Frei Cancer Medicine) by M.D. Bast, Robert C., Jr., M.D. Byrd, John C., et al. Apr 25, 2023 (Wiley-Blackwell) 3. Cancer Cell Biology: Methods and Protocols by Sherri L. Christian. Jun 23, 2022 (Humana) 4. Others