睡眠轉譯醫學
Sleep translational medicine
| 節 | 週二 |
|---|---|
9 17:30–18:20 | 睡眠轉譯醫學 YL402 2 節連堂 |
A 18:30–19:20 |
* 根據陽明交大上課時間表所列
每位學生藉由親自實驗操作,了解生物醫學訊號的儀器設計及其分析、使用方式。並搭配相關教材與論文選讀,了解目前基礎與臨床研究實際運用狀況。課程中學生輪流上台報告綜論論文或綜合多篇論文,並分析研究方向的重要性。藉由輪流報告及討論方式,使同學們能對此研究議題更有認識及增加研究興趣。By doing experiments personally, every student would understand the instrument design, analyze and operation of biomedical signal. Combining with instrument related articles, students follow up with current application of basic research and clinical one. Each student is required to present a review article or summarize several articles as well as analyze the significance of their research. By presenting reports and discussion during class, it would encourage students to understand on research topic and further gain the interest on research.
以各別研究主題為目標,將背景相關資訊詳細探索及了解,內容包括組織、解剖、生理、神經科學、行為學以及生醫資訊等跨領域常識。學生能在課程中更深入瞭解睡眠以及其相關學術研究的重要性。This course aims at providing individual research themes for students to discover and better understand background knowledge in different fields. Topics covered include histology, anatomy, physiology, neuroscience and behavioral science, biomedicine, which cross fields of common knowledge. The students will be able to understand more about the importance of the sleep academic research.
課中報告 50%(口頭報告) 期末評量 50%(測驗) 課堂表現 加減分5%Midterm Assessment 50%(Presentation) Final Assessment 50%(Presentation) Attendance and Performance ±5%
| 週次 | 主題 |
|---|---|
| 第 1 週 | 睡眠醫學與睡眠衛生導論Introduction to Sleep Medicine and Sleep Hygiene |
| 第 2 週 | 心律變異性與自律神經系統Heart Rate Variability and the Autonomic Nervous System |
| 第 3 週 | 探討多模式聲刺激模型對於健康人及自覺型失眠患者在睡眠、注意力、記憶力之影響 Investigating the effects of multimodal auditory stimulation models on sleep, attention, and memory in healthy individuals and individuals with subjective insomnia. |
| 第 4 週 | 不同環境溫度對於健康人與亞健康者的主觀感受及睡眠期間自律神經功能與腦波的差異 Examining the subjective perception and autonomic nervous system function, as well as differences in brain waves, during sleep in healthy individuals and individuals with suboptimal health under different environmental temperatures. |
| 第 5 週 | 探討睡姿及相關環境因子對睡眠呼吸中止症病人嚴重度的影響並討論改善方案及機轉 Exploring the impact of sleep position and related environmental factors on the severity of sleep apnea in patients and discussing improvement strategies and mechanisms. |
| 第 6 週 | 社區老人生理失能與認知障礙之性別差異,及運動介入與穿戴裝置使用之效益:聚焦於阻塞型睡眠呼吸中止症與憂鬱症 Examining gender differences in physiological disabilities and cognitive impairments among older adults in the community, focusing on obstructive sleep apnea and depression, and evaluating the benefits of exercise intervention and the use of wearable devices. |
| 第 7 週 | 益生菌改善睡眠指標的功效性評估 Assessing the efficacy of probiotics in improving sleep indicators. |
| 第 8 週 | 運用穿戴式裝置與人工智慧音樂改善焦慮合併失眠症狀:建立即時監測回饋儀器系統 Utilizing wearable devices and artificial intelligence music to improve anxiety and comorbid insomnia symptoms, establishing a real-time monitoring and feedback instrument system. |
| 第 9 週 | 以憂鬱症、肥胖及糖尿病大鼠模式縱向紀錄生理訊號之日夜節律和生化參數、代謝基因與腸道菌變化: 給予光照週期相位移介入再回復、滾輪運動及益生菌介入的改善效果 Longitudinally recording physiological signals, circadian rhythms, biochemical parameters, metabolic genes, and gut microbiota changes in rat models of depression, obesity, and diabetes: investigating the effects of light-dark cycle phase shift intervention, wheel exercise, and probiotic intervention on recovery. |
| 第 10 週 | 聲音刺激對於睡眠與認知的影響The Impact of Sound Stimulation on Sleep and Cognition |
| 第 11 週 | 睡眠姿勢之判讀與偵測及臨床應用Interpretation and detection of sleep position |
| 第 12 週 | 腦波訊號之處理與分析Processing method and analysis of EEG signals |
| 第 13 週 | 基於心率變異率判讀睡眠週期Distinguish sleep cycle based on heart rate variability |
| 第 14 週 | 頻率共振微電流治療舌骨周圍肌群後對於睡眠呼吸中止症改善之成效評估 Evaluating the effectiveness of frequency-specific microcurrent therapy around the genioglossus muscle for improving sleep apnea. |
| 第 15 週 | 探討睡眠呼吸中止模式條件每次低氧維持時間或低氧發生頻率長期介入對大鼠心循環系統及認知功能影響及機轉: 高血壓、睡眠結構、自律神經以及促紅血球生成素的角色 Investigating the long-term effects and mechanisms of intervention in the pattern of sleep apnea, focusing on the duration of each episode of hypoxia or the frequency of hypoxic events, on the cardiovascular system and cognitive function in rats: role of hypertension, sleep architecture, autonomic nervous system, and erythropoietin. |
| 第 16 週 | 探討透明矯正器有別於傳統下顎前伸裝置及快速上顎擴張功能性矯正裝置對睡眠呼吸障礙的創新療法 Exploring the innovative treatment of sleep-disordered breathing using transparent aligners, distinct from traditional mandibular advancement devices and rapid maxillary expansion functional orthodontic appliances. |
1.楊靜修等編著,《心率變異研究: 從健康養生到疾病診療》 2.Kuo, T. B. J.* The development and application of an analysis system for physiological rhythms. Tzu Chi Medical Journal 13:113-129, 2001郭博昭論文選輯ftp://120.126.40.160/paper 3. Chapman, Electric Machinery Fundamentals 4/E, McGRAW-HILL, 2005