奈米生醫感測
Nano Biosensing
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 奈米生醫感測 EE117 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
With the achievements of nanotechnology and nanoscience, a wide variety of nanoscale materials and devices with different sizes (1–100 nm), shapes, and compositions have been introduced to biosensing. The small sizes of nanoparticles and nanodevices break through the limitation of structure miniaturization, leading to a lower detection limit, even reaching zeptomolar concentrations. Based on fundamentals of theories, this course introduces novel principles and detection strategies in the area of biosensing for nanomaterials and nanodevices. Each topic provides a theoretical overview of different topics and the correspondent interesting bioanalytical applications. The most exciting and unique aspect of this course is that the utilization of nanomaterials and nanodevices not only enhances the biosensing capabilities, but also brings out newer approaches such as reagent-less biosensing, label-free biosensing, and single molecular detection.
近代物理(Modern Physics) 基礎化學(Chemistry) 基礎生物(Biology) 半導體元件物理(Semiconductor device physics)
Slides in ppt
(1) Midterm Exam 40% (2) Final Exam 40% (3) Home works, Final report and presentation 20%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to nanobiosensors- Why nanobiosensing- Types of nanobiosensors- Basic Concepts: Biomolecules, Analyte Density, Diffusion Distances- Basic Concepts: Types of Biosensors, Geometry of Biosensing |
| 第 2 週 | Diffusion on nanobiosensors |
| 第 3 週 | Silicon NanoFETs as biosensors- Why nanoFETs instead of MOSFETs?- Electrical models in biosensing- Limitations of NanoFETs as biosensors- beyond nanoFETs |
| 第 4 週 | Geometry effect on nanobiosensors- settling time- Shape of a Surface- Sensors with Complex Geometry- Beating the Limits- Droplet Evaporation |
| 第 5 週 | Geometry effect on nanobiosensors- Beating the Diffusion Limit:Enhanced Diffusion and Fluid Flow- Passage and Escape Time |
| 第 6 週 | Sensitivity- Nanobiosensors Sensitivity and Types of Biosensors- Potentiometric Sensors: Charge Screening for a Planar Sensor- Potentiometric Sensors: Charge Screening for |
| 第 7 週 | Cylindrical Sensors- Potentiometric Sensors: ISFET as a pH-Meter- Potentiometric Sensors: Why are Biomolecules Charged?- Debye screen length |
| 第 8 週 | Holiday |
| 第 9 週 | Exam #1 (take-home exam)Papers and presentation topics assign and send to students |
| 第 10 週 | Sensitivity- Amperometric Sensors - Glucose Sensor - Amperometric Sensors: Beating the Diffusion Limit by Nanogap Amperometry- Cantilever-based Sensors- Noises etc. |
| 第 11 週 | Selectivity and system considerations- Introduction and Molecular Recognition- Physics of Sequential Adsorption- Tag, filer and amplify |
| 第 12 週 | Nanostructured Biosensing and Biochips for DNA Analysis- Nanostructures in DNA Biosensing- Nanostructures for DNA Biochips |
| 第 13 週 | Gas sensors review:Nitric Oxide Sensing- Importance of NO- In vivo and in vitro NO detection- Nanosensors in NO Detection |
| 第 14 週 | Selectivity - Introduction and Molecular RecognitionSelectivity - Physics of Sequential AdsorptionSelectivity - When all else fails, tag, filer and amplifySelectivity - Noise Tranducers |
| 第 15 週 | Putting the Pieces Together - Genome Sequencer IPutting the Pieces Together - Genome Sequencer IIPutting the Pieces Together - Genome Sequencer IIIPutting the Pieces Together - Concluding Thoughts |
| 第 16 週 | Final Exam and presentation |
| 第 17 週 | |
| 第 18 週 | |
| 第 19 週 | |
| 第 20 週 | |
| 第 21 週 |
1) NanoBiosensing, Principles, Development and Application, ISBN 978-1-4419-9621-3, 2011—textbook #1 2) NanoBiosensing, ISBN 978-1-4419-6168-6, 2011—textbook #2 3). Handouts extracted from latest research articles
- 地點
- 田家炳616A
- 時間
- Monday 15:00~16:00 Wednesday 13:30 ~14:30
- 聯絡方式
- 55805 sheujt@nycu.edu.tw