進階有機化學

Advanced Organic Chemistry---2024 spring semester A. Course Description The course in advanced organic chemistry gives a deeper understanding of the structures of organic compounds and the mechanisms of organic reactions. The goal is to allow students to build on the foundation of organic chemistry and attain a level of knowledge and understanding that will permit them to comprehend much of the material that appears in the contemporary chemical literature. B. Lecturers Dr. Steve S.-F. Yu 俞聖法 (sfyu@gate.sinica.edu.tw) C. Lecture time & place Thursdays 13:30-16: 30, classroom B105 (3 sessions/week, 50 min/session) G. Lecture Dates and Syllabus February 22 Chemical Bonding and Molecular Structure February 29 Stereochemistry and Conformation March 7 Stereo-selectivity March 14 Thermodynamic Stability and Chemical Kinetics March 21 Structural Effects on Stability and Reactivity March 28 Special Topics in Advanced Organic Chemistry April 4 Children Day Holiday April 12 Midterm Exam A. Course Description The course in advanced organic chemistry gives extended knowledge in the field of organic synthesis. The students will gain a deeper understanding of advanced synthetic methods as well as a broader knowledge regarding organic reactivity. The important aspects of reactivity and selectivity of a particular transformation within the field of organic synthesis will be discussed in this course. In particular, organic reactions for controlling the chemo-, regio- and stereoselectivity are highlighted. B. Lecturers Dr. Wen-Shan Li 李文山 (wenshan@gate.sinica.edu.tw) C. Lecture time & place Thursdays 13:30‐16:30, classroom B105 (3 sessions / week, 50 min / session) G. Lecture Dates and Syllabus April 18 Nucleophilic Substitution and Elimination April 25 Oxidations and Reductions May 2 Reactions of Aromatic Compounds May 9 Photochemistry and Free-Radical Reactions May 16 Cycloadditions and Rearrangements May 23 Organometallic Compounds in Organic Synthesis May 30 Transition Metal-Catalyzed and Mediated Reactions June 6 Final Exam

F. Teaching Method Oral

D. Text Book "Advanced Organic Chemistry, Part A: Reactions and Synthesis" by Francis A. Carey and Richard J. Sundberg. 5th edition. New York, NY: Springer, 2007. E. References "March’s Advanced Organic Chemistry: Reactions, Mechanisms and Structures" by Michael B. Smith and Jerry March, Hoboken, New Jersey, John Wiley & Sons Inc., 2007. D. Text Book "Advanced Organic Chemistry, Part B: Reactions and Synthesis" by Francis A. Carey and Richard J. Sundberg. 5th edition. New York, NY: Springer, 2007. E. References 1. "The Art of Writing Reasonable Organic Reaction Mechanisms" by Robert B. Grossman, New York, NY: Springer. II. “The Logic of Chemical Synthesis” by E. J. Corey and Xue-Min Cheng, John Wiley & Sons, Inc.