存活資料分析
Survival Analysis
學期
113-1
學分
2
學分
當期課號
130204
永久課號
MDPH30023
開課單位
公共衛生研究所
授課教師
陳瓊梅
校區
陽明
類別
必修
上課時間表
| 節 | 週三 |
|---|---|
3 10:10–11:00 | 存活資料分析 YS107 2 節連堂 |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
概述
1.存活資料的產生 2. 衡量存活資料的統計方法 3. 無母數分析法、有母數分析法、半參數分析 4. 多變量存活資料 1. The characteristics of incomplete survival data 2. Measures of survival data 3. Nonparametric models, parametric models and semiparametric models 4. Multivariate survival data
評分方式
HW 50% Mid-term exam and Final exam 50%
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | 1.Introduction 2.Incomplete data property: censoring and truncation |
| 第 2 週 | 1. Typical censoring mechanisms2. Data coding3. Survival rate 4. Survival functions, hazard function and cumulative hazard function |
| 第 3 週 | 1.Likelihood function for right-censored data2.Likelihood function for interval-censored data |
| 第 4 週 | 1.Parametric regression model of parametric models2.Parametric analysis: widely used distributions 3.Parametric accelerated failure time (AFT) model |
| 第 5 週 | 1.MLE 2.R program for parametric survival analysis (I) |
| 第 6 週 | R program for parametric survival analysis (II) |
| 第 7 週 | Mid-term exam |
| 第 8 週 | 1.Introduction to Nonparametric analysis2.Nonparametric analysis: Kaplan-Meier estimation |
| 第 9 週 | Nonparametric analysis: Testing Gehan’s test (extension of Wilcoxon test) log-rank test (Mantel-Haenszel test) |
| 第 10 週 | Semiparametric regression models: Cox’s PH model (I) |
| 第 11 週 | Semiparametric regression models: Cox's PH model (II) |
| 第 12 週 | Cox's PH model: time - stratification, time-varying covariates, diagnosis |
| 第 13 週 | Cluster survival data (I): Modeling: marginal model, frailty model and copula model |
| 第 14 週 | Cluster survival data (II): Data analysis |
| 第 15 週 | Competing risks data and multi-state model-(I) |
| 第 16 週 | Competing risks data and multi-state model-(II) |
教科書
1. The Statistical Analysis Of Failure Time Data / John D. Kalbfleisch, Ross L. Prentice : c2002 2. Statistical Models And Methods For Lifetime Data / Jerald F. Lawless : 2003 3. Survival Analysis: Techniques for Censored and Truncated Data, Statistics for Biology and Health/ Klein, John P.; Moeschberger, Melvin L. c1997 4. Survival Analysis/ Miller: 1981