風險評估數學模擬
Mathematical Modeling for Risk Assessment
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 風險評估數學模擬 YN205 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
The primary objective is to provide students with a basic understanding of the principles of mathematical and statistical modeling, including benchmark dose (BMD) model, probabilistic analysis (mainly Monte Carlo simulation), pharmacokinetics (PK)/toxicokinetics (TK), pharmacodynamics (PD)/toxicodynamics (TD), and physiologically based pharmacokinetic (PBPK) models. Also, to promote students to understand how these models/methods are applied in risk assessment.
1. Class participation and performance (30%) 2. Class exercises (50%) 3. Final exercises (20%)
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to the course |
| 第 2 週 | Introduction to the benchmark dose (BMD) model |
| 第 3 週 | Introduction to BMD model; BMD model exercises (I) |
| 第 4 週 | BMD model exercises (II) |
| 第 5 週 | Introduction to the probabilistic risk assessment (PRA) |
| 第 6 週 | Introduction to the PRA |
| 第 7 週 | PRA exercises (I) |
| 第 8 週 | PRA exercises (II) |
| 第 9 週 | PRA exercises (III) |
| 第 10 週 | Introduction to pharmacokinetic (PK)/toxicokinetic (TK) modeling |
| 第 11 週 | Introduction to PK/TK modeling |
| 第 12 週 | Introduction to physiologically based pharmacokinetic (PBPK) modeling |
| 第 13 週 | Introduction to PBPK modeling |
| 第 14 週 | PBPK exercises (I) |
| 第 15 週 | PBPK exercises (II) |
| 第 16 週 | PBPK exercises (III) |
BMD modeling: 1. U.S. EPA. 2012. Benchmark Dose Technical Guidance. Washington, DC: U.S. Environmental Protection Agency. TK/PK, TD/PD, and PBPK: 1. Southwood R, Fleming VH, Huckaby G. 2018. Concepts in Clinical Pharmacokinetics (7th edition). Bethesda, MD: American Society of Health-System Pharmacists. 2. Shargel L, Yu ABC. 2015. Applied Biopharmaceutics & Pharmacokinetics (7th edition). New York: McGraw-Hill Education. 3. Hayes AW, Kruger CL. 2014. Hayes’ Principles and Methods of Toxicology (6th edition). Boca Raton, FL: CRC Press. 4. Reddy MB, Yang RSH, Clewell HJ III, Andersen ME. 2005. Physiologically Based Pharmacokinetic Modeling: Science and Applications (1st edition). Hoboken, NJ: John Wiley & Sons, Inc. 5. Fisher JW, Gearhart JM, Lin Z. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk (1st edition). Cambridge, MA: Academic Press. 6. U.S. EPA. 2006. Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment. Washington, DC: U.S. Environmental Protection Agency. 7. WHO. 2010. Characterization and Application of Physiologically Based Pharmacokinetic Models in Risk Assessment. Geneva: World Health Organization.