高等有機化學(一)

Prof. Y. Tobe: The course will be taught using the contents of Advanced Organic Chemistry, Part A (Chapters 1-3 and 8, sections indicated below) and the materials prepared by the teacher. Prof. Y.-K. Wu: The course will be taught using the contents of Advanced Organic Chemistry, Part A (Chapter 10) and Part B (chapters 6 and 13) and the materials prepared by the teacher. The goal of our course is to enable students to build on the foundation of organic chemistry and extend their knowledge to synthetic applications. The course allows the students to attain a level of knowledge to understand much of the material that appeared in contemporary chemical literature.

Students should finish Undergraduate Organic Chemistry I and II. As the course will be given in English, students should have the ability for English listening and writing.

Prof. Y. Tobe (50%): There will be three or four short exercises during the course in addition to the mid-term exam (Oct. 21, 2024). Attending each exercise counts as 1 point. The final score is a total of 50 points, which is the sum of the scores of the exercises and the mid-term exam. Prof. Y.-K. Wu (50%): The scores are based on the final exam (Dec. 16, 2024). The date of the mid-term and final exams will be announced in the class.

1. Carey, F. A.; Sundberg, R. J. Advanced Organic Chemistry: Part A, 5th Ed.; 2007. 2. Carey, F. A.; Sundberg, R. J. Advanced Organic Chemistry: Part B, 5th Ed.; 2007. For registered students, the electronic version of the textbooks can be downloaded for free via NYCU library website. Detailed Contents Given by Prof. Y. Tobe (AOC, Part A): Chapter 1. Chemical Bonding and Molecular Structure -Valence Bond Theory and Molecular Orbital Theory ... sections 1.1-1.2 -The Hückel MO Method and its Application ... section1.2.1 -Other MO Calculation Methods ... sections 1.2.2-1.2.4 -Perturbation in MOs and Frontier MOs ... section 1.2.5 -Electron Density Functional Method ... section 1.3 -Electron Density Distribution ... sections 1.4.1-1.4.2, 1.4.5 -Hyperconjugation ... Topics 1.1-1.2 Chapter 2. Stereochemistry, Conformation, and Stereoselectivity -Configuration ... section 2.1 -Conformation and Conformation Analysis ... section 2.2 and additional materials -Molecular Mechanics ... section 2.3 -Separation of Enantiomers ... Topic 2.1.2 -Anomeric Effect ... Topic 2.3 Chapter 3. Structural Effect on Stability and Reactivity -General Relationships between Thermodynamic Stability and Reaction Rates ... section 3.3 -Electronic Substituent Effects on Reaction Intermediates ... section 3.4 -Kinetic Isotope Effect ... section 3.4 -Linear Free-Energy Relationships for Substituent Effects ... section 3.6 Chapter 8. Aromaticity -Criteria of Aromaticity ... section 8.1 -Examples of Aromatic and Antiaromatic Molecules ... sections 8.2-8.6 Various Types of Aromaticity ... additional materials Contents Given by Prof. Y.-K. Wu: AOC, Part A Chapter 10. Concerted Pericyclic Reactions AOC, Part B Chapter 6. Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations Chapter 13. Multistep Syntheses

時間

In case you have questions concerning the course, students may contact or make an appointment with Prof Tobe and Wu via e-mail.

聯絡方式

Prof. Yoshito Tobe Office: SB335 E-mail: tobe@nycu.edu.tw Prof. Yen-Ku Wu Office: SB305B E-mail: yenkuwu@gmail.com Website: www.ykwulab.com