醣化學
Carbohydrate Chemistry
| 節 | 週四 |
|---|---|
7 15:30–16:20 | 醣化學 3 節連堂 |
8 16:30–17:20 | |
9 17:30–18:20 |
* 根據陽明交大上課時間表所列
製作結構明確的聚醣能力對於現代醣生物學來說是非常重要的。這類化合物是探測及探討與醣相關的生物學的寶貴分子,它們也可以被開發成疫苗,並作為藥物開發的先驅化合物。本課程將為學生提供現代合成醣在化學上的知識基礎,使學生能夠在往後的研究中實行或激起對醣更深入的探討。課程重點將放在醣合成的化學上,且包括碳水化合物活性酶(CAZymes)和它們在醣苷鍵合成中的應用。此外,還將討論使用核磁共振光譜來描述醣的特徵,以及探測醣結合蛋白對醣結合的方法。下一頁將提供更詳細的課程安排。 The ability to make structurally-defined glycans is essential for modern glycobiology. Suchcompounds are invaluable probes of glycan-mediated biology and they can also be used to generatevaccine candidates and serve as lead compounds for drug development. This course will providestudents with an understanding of modern synthetic carbohydrate chemistry and give them aknowledge base that will allow further investigation either through independent study or in thelaboratory. The focus will be primarily on synthetic carbohydrate chemistry, however, carbohydrateactive enzymes (CAZymes) and their use in glycoside bond synthesis will also be covered. Inaddition, methods to characterize glycans using NMR spectroscopy and probe the binding ofglycans by glycan-binding proteins will be discussed. A more detailed course schedule is providedon the next page. 該課程的目標是讓學生了解現代醣化學,特別是複雜醣類的合成。 The objective of the course is to provide students with an understanding of modern carbohydratechemistry, in particular the synthesis of complex glycans. 大 學有機化學。第一節課將涵蓋/複習有機和物理化學的關鍵概念,這些概念是進入課程材料所需的,並確保每個人都從一個共同的基礎開始。 Undergraduate organic chemistry. Thefirst lecture will cover/review key concepts in organic and physical chemistry required to access thecourse material and ensure everyone is starting from a common foundation.
本課程以英語授課。需先修「有機化學」。 總人數上限:40人
| 週次 | 主題 |
|---|---|
| 第 1 週 | 關鍵的有機和物理化學概念;碳水化合物結構和構型 Key Organic and Physical Chemistry Concepts; Carbohydrate Structure andConformation |
| 第 2 週 | 碳水化合物的結構和構型;降解反應; 保護基 Carbohydrate Structure and Conformation; Degradative Reactions; Protecting Groups |
| 第 3 週 | 保護基Protecting Groups |
| 第 4 週 | 保護基Protecting Groups |
| 第 5 週 | 功能基的相互轉化Functional Group Interconversions |
| 第 6 週 | Holiday |
| 第 7 週 | 功能基的相互轉化Functional Group Interconversions |
| 第 8 週 | 合成單醣的新方法 De Novo Synthesis of Monosaccharides |
| 第 9 週 | 期中考試Mid Term Exam |
| 第 10 週 | 醣苷鍵的化學合成Chemical Glycosidic Bond Formation |
| 第 11 週 | 醣苷鍵的化學合成Chemical Glycosidic Bond Formation |
| 第 12 週 | 醣苷鍵的化學合成Chemical Glycosidic Bond Formation |
| 第 13 週 | CAZymes和醣苷鍵的酶催化合成CAZymes and Enzymatic Synthesis of GlycosidicBonds |
| 第 14 週 | 碳水化合物的核磁共振和醣蛋白結合的生物物理學測量NMR of Carbohydrates andBiophysical Measurements of Glycan–Protein Binding |
| 第 15 週 | 研究計劃報告Research Proposal Presentations |
| 第 16 週 | 期末考試Final Exam |
課程筆記將由教師提供。