有機化合物光譜分析及數據整合

有機化合物光譜分析及數據整合Characterization and Data Reporting of Organic Compounds 生化科學研究所 Dr. Todd L. Lowary (呂桐睿 博士)能以光譜數據分析有機化合物的結構是在有機、 生物及藥物化學研究中非常重要的一環。在收集並分析完這些光譜後,將此數據整合並依照固有格式撰寫完整的一份報告對於這些研究領域的發展是不可或缺的。在這門課程中,學生將學習 (一 如何整合光譜數據紅外線光譜、質譜、一維及二維核磁共振光譜以解析有機化合物的結構(二)將此數據依照有機、生物及藥物化學研究領域之固有格式撰寫 。 這項課程將使用學術及非學術記載 的有機化合物 光譜 來培養學生解析整合光譜的能力。 An important part of research in organic, bioorganic and medicinal chemistry is the characterization of organic compounds, typically by spectroscopic means to elucidate their structure. After data collection and analysis , it is then necessary to report the data in a manner acceptable to the research community, thus facilitating the progress of these areas In this course, student s will learn how to 1) employ widely used spectroscopic and spectrometric methods (IR, MS, 1D 2D NMR) to characteriz e and determine the structure of organic compounds 2)2): write up the data in a format accepted by the organic, bioorganic and medicinal research communities. The course will involve extensive problem solving using data from both reported and unreported com pounds. 以紅外線、質譜及核磁共振光譜學解析及統整有機化合物的結構並以學術固有 之格式撰寫完整的數據報告。 To identify organic compounds using IR spectroscopy , MS spectrometry , and 1D /2D NMR spectroscopy and report the data and analysis results in a format acceptable for scientific publication. 說明: 化學所有開類似的課程不 過並不頻繁(大約每兩年一次)。且該課程僅有課堂講課 並沒有著重在提升學生解析光譜的能 力,亦無指導如何撰寫符合 格式的實驗細節報告。因此此新開 之 課程 的 著重點與該課程並不重疊。此外,需要此課程的人多為剛開始做有機、生物及藥物化學研究的學生(約為大三、 大四、碩一、博一生),因此化學系該課程的開課頻率並不理想。 A similar course is taught in the Department of Chemistry ( DoC), but not on a regular basis (~once every t wo years). The DoC course is a classroom based and does not have a focus on problem solving and data reporting. T he focus of the proposed course is therefore complementary . Moreover, a course of this type is best taken by students at the start of their research career in organic, bioorganic and medicinal chemistry (senior undergraduate students or first year graduate students). The frequency of the existing course in the DoC is therefore not ideal. 這門課程將由呂桐睿博士主要授課導師 及一位該實驗室的博士後 學者 朱駿叡共同授課。朱博士擁有此課程所需之多年經驗且得過關於教學之獎項。呂博士 為此課程之負責人,負責授課、 評估 成績及處理任何關於 課程上的問題。此課程 將 吸引 欲研究合成有機分子的 台大學 、碩、博士學程及中研院國際研究生學程 TIGP 中生化及分生物理學 學程( CBMB )、永續科學及化學科技學程(SCST 學程的學生 修課 。 The course will be co taught by both the instructor of record (Lowary) and a senior postdoctoral fellow in his laboratory, Dr. Chun Jui Chu. Dr. Chu is an expert i n the characterization and reporting of data for organic compounds and is an award winning teacher. Lowary will take full responsibility for the delivery and evaluation of the course and any problems that arise . It is anticipated that this course will be o f interest to NTU undergraduate, M. Sc. and Ph. D. students with r esearch interest s in the synthesis of organic molecules. Students enrolled in the Chemical Biology and Molecular Biophysics and Sustainable Science and Chemical Technology subprograms of the Taiwan International Graduate Program are also anticipated to be potential enrollees .

大學有機化學。

課程進行方式 上課頻率為 每周兩小時, 由一般講課及習題 講 習所組成,旨在 提升學生的光譜分析及解決問題能力。 成績評估方式如下。 The course will be given once a week in a two hour block, and will consist of lectures and workshops intended to foster problem solving skills . Evaluation methods are detailed below

Organic chemistry (6th edition or later), L. G. Wade Jr. (Spectrometric identification of organic compounds (7th edition or later ), R. M. Silverstein, F. X. Webster, D. J. Kiemle (Organic chemistry data & info spectroscopy resources ( Organic Chemistry Data Links: https://organicchemistrydata.org/links/#spectroscopy_resources