生物化學特論

生物化學涵蓋範圍廣泛,也是生物醫學領域重要的基礎科目之一。本課程主要著重在生物代謝的部分,也就是生物能量的轉換與產生,如何透過細胞內的酵素與輔酶的作用將攝取的養分轉換成能量,以及過多的能量如何儲存。不同養分之間又是透過何種途徑互相轉換,以及在這些過程中的關鍵分子為何,都將在此課程中一一介紹。最後,在人體內不同器官各司何種代謝功能,以及代謝分子如何在器官之內流通,也將在此課程中介紹。最後,本課程也會介紹當這些代謝途徑因某些重要酵素突變,而失去功能後將導致那些遺傳性疾病。Biochemistry is one of the most important basic courses in the field of biomedicine, and it widely covers several topics in biophysics and biochemicals, biomolecules, enzymatics, metabolism, and genetic information. In this class, we focus on the bioenergy conversion and metabolism that are mediated through enzyme/coenzyme activity. How nutrients are catabolized in cells, and how micromolecules are anabolized to macromolecules for energistic conservation. The interconversion between different types of biomolecules, as well as the critical intermediates will also be introduced. Furthermore, the nutrients metabolism in various organs, and the transport of metabolites among organs are also important parts of this course. The diseases caused by genetic inability of metabolic pathways are also discussed here.

了解大分子生化物質,包括醣類、核酸、蛋白質、脂質等代謝之生物化學過程,以及代謝失衡後與疾病發生之間的關係。To understand the biochemical metabolism of macromolecules, including carbohydrates, nucleic acids, proteins and lipids, and the etiology of metabolic diseases

a. 期中報告與期末報告: 各40% b. 出席率 : 20% a. Midterm and Final examinations: 40% each b. Attendance : 20%

a. Biochemistry, 3rd Ed. 2004, Voet, D., and Voet, JG, John Wiley & Sons Inc. USA b. Mark’s Basic Medical Biochemistry – A clinical approach, 2nd Ed 2005, Colleen Smith, Allan D. Marks, Michael, Lieberman, Lippincott Williams & Wilkins, USA c. 教師handout