代謝工程學

Metabolic Engineering

學期

114-1

學分

3 學分

當期課號

430016

永久課號

BTBT30196

開課單位

生物科技學系

授課教師

蘭宜錚

校區

博愛

類別

選修

上課時間表

節	週一
5 13:20–14:10	代謝工程學 BI301 3 節連堂
6 14:20–15:10
7 15:30–16:20

* 根據陽明交大上課時間表所列

概述

代謝工程廣泛的定義為:以基因工程技術來改變細胞內的代謝途徑以及其調控功能而導致所想要的細胞表型。代謝工程目前是廣泛使用的技術來提高菌體生物質量或代謝物產量,可生產的代謝物質涵蓋能源分子、高分子單體、溶劑、染劑、藥物起始物等眾多工業上所需化合物。本課程目的是讓學生認識以及熟悉代謝工程學以及它在生化產業的應用,本課程強調生產生質化學品的生化反應與途徑。 Metabolic Engineering is broadly defined as using genetic tools to modify the cellular metabolic pathways and regulations to achieve a particular phenotype. Such phenotype typically includes the optimization of biomass formation and/or production of valuable compounds including those that form biofuels, biochemicals, drug precursors, etc. The goal of this course is to familiarize students with the field of metabolic engineering and its application in current biochemical industry. This course focuses on the biochemistry and metabolic pathways for the production of useful biochemicals.

先修科目

先修科目或先備能力:生物化學(二)或相關生化(代謝)基礎. Biochemistry II or general knowledge of metabolism is required.

教學方式

Slides will be posted online via E3

評分方式

Exam: 50% Project Presentation: 50%

週次計畫

週次	主題
第 1 週	Course Introduction, background material review
第 2 週	Catabolism of carbohydrates and relevant resource
第 3 週	Photosynthesis and carbon fixation pathways
第 4 週	Photosynthesis and carbon fixation pathways
第 5 週	National Holiday No Class
第 6 週	National Holiday No Class
第 7 週	Utilization of emerging feedstocks
第 8 週	Cellular Redox balance and products produced via fermentation
第 9 週	Metabolic engineering for biofuel production
第 10 週	Metabolic engineering for platform chemical productions
第 11 週	Metabolic engineering for pharmaceutical and nutraceutical productions
第 12 週	Development of selection platforms for directed evolution
第 13 週	Current special topics
第 14 週	Current special topics
第 15 週	Course exam
第 16 週	Project presentations

教科書

Lecture slides & Recent journal publications including primary research and review articles

Office Hours

地點: BI-724
時間: To be announced
聯絡方式: Email: ethanilan@nycu.edu.tw