綜合發育神經學
Comprehensive Developmental Neuroscience
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 綜合發育神經學 YEA100 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
探索神經發育過程中,基因、分子與細胞機制對於理解神經系統疾病至關重要。本課程從基因、分子與細胞方向出發,加以解剖學與胚胎發育學的角度,綜合歷史觀點到最新的科學發展,討論神經疾病的產生與其造成的表徵和影響的層面。希望對基礎、轉化與臨床應用有全面性的了解。 The genetic, molecular and cellular mechanisms of neural development is the basis to understand nervous system disorders. In this course, we will combine the knowledge of genetic, molecular and cellular mechanisms in neuroanatomy and embryology from the historical perspectives to up-to-date references to discuss the causes of nervous system disorders and the impacts on phenotype and pathological features. We hope to provide information to broadly understand the basic, translational and clinical applications.
1.統整神經發育的重要事件 2.分析影響神經迴路的因素 3.列出檢測行為表徵的方法跟原理 3.結合發育要件建構臨床相關疾病的機轉 1. Summarize the key events in neurological development 2. Analyze the factors involved in constructing neural circuits 3. List the methods to examine the behaviors and the underlying principles 4. Integrate the developmental keys to the clinical related neurological disorders.
出席率、討論參與率與期中、期末報告。Attendance, midterm and final report
| 週次 | 主題 |
|---|---|
| 第 1 週 | Neurogenesis and brain development 1 |
| 第 2 週 | Neurogenesis and brain development 2 |
| 第 3 週 | Neurogenesis: Cell cycle and signaling 1 |
| 第 4 週 | Neurogenesis: Cell cycle and signaling 2 |
| 第 5 週 | Brain growth, patterning, morphogens and evolution 1 |
| 第 6 週 | Brain growth, patterning, morphogens and evolution 2 |
| 第 7 週 | Adult neurogenesis and related disorders 1 |
| 第 8 週 | Adult neurogenesis and related disorders 1 |
| 第 9 週 | Structural brain development 1 |
| 第 10 週 | Structural brain development 2 |
| 第 11 週 | Modeling in vivo brain development 1 |
| 第 12 週 | Modeling in vivo brain development 2 |
| 第 13 週 | Modeling in vivo brain development 3 |
| 第 14 週 | Modeling in vivo brain development 4 |
| 第 15 週 | Genes and neurological disorders 1 |
| 第 16 週 | Genes and neurological disorders 2 |
Patterning and Cell Type Specification in the Developing CNS and PNS, 1st Edition, John Rubenstein Pasko Rakic, ISBN: 9780123972651 Neural Circuit Development and Function in the Healthy and Diseased Brain,1st Edition, John Rubenstein Pasko Rakic, ISBN: 9780123972675