微流體科技

課程概述與目標： Current drug screening and safety testing paradigms are costly and time-consuming, requiring approximately 15 years and over $2 billion to bring a single compound to market. Despite these efforts, late-stage drug attrition remains common. Traditional animal models and 2D in vitro systems used during preclinical drug development fail to accurately replicate human physiology and pathophysiology, limiting their predictive power for human biology and disease mechanisms. To address these challenges, novel approaches are essential for making drug discovery more affordable and effective. The motivation for developing accurate and predictive models is twofold: To study and develop new treatments for pathologies that contribute significantly to global morbidity and mortality. Screening for adverse drug reactions in different organs is a critical factor in drug development. In recent years, organ-on-a-chip systems—three-dimensional in vitro models—have emerged as innovative tools for mimicking the physiological conditions of healthy and diseased tissues. These platforms offer a promising alternative to animal models, providing more accurate and human-relevant data for drug screening and discovery applications. This course explores the current state of organ-on-a-chip technology, highlighting its design, applications, advantages, and limitations in modeling healthy and pathological tissues. We will also delve into the commercialization journey of these advanced platforms, equipping students with a comprehensive understanding of their potential impact on the future of drug development. 本課程旨在將學生介紹到芯片工程中的新興領域。它對研究生和大學部學生開放。 當前的藥物篩查和安全測試範例是昂貴且耗時的，需要大約15年，超過20億美元才能將單個化合物推向市場。儘管做出了這些努力，但後期藥物損耗仍然很普遍。臨床前藥物開發期間使用的傳統動物模型和2D體外系統無法準確複製人類的生理學和病理生理學，從而限制了其對人類生物學和疾病機制的預測能力。 為了應對這些挑戰，新穎的方法對於使藥物發現更加負擔得起和有效至關重要。開發準確和預測模型的動機是雙重的： 研究和開發對全球發病率和死亡率產生重大貢獻的病理的新療法。 篩查在不同器官中的藥物反應是藥物發育的關鍵因素。 近年來，片上的組織系統（三維體外模型）已成為模仿健康和患病組織的生理狀況的創新工具。這些平台為動物模型提供了一種有希望的替代方法，為藥物篩查和發現應用提供了更準確和與人類相關的數據。 本課程探討了機器上芯片技術的當前狀態，突出了其設計，應用，優勢和局限性在健康和病理組織中的局限性。我們還將深入研究這些高級平台的商業化旅程，使學生對他們對藥物開發未來的潛在影響有全面的了解。

This opportunity is designed for graduate and undergraduate students for attending the EMI course. Students in life sciences, biomedical engineering, mechanical engineering, chemical engineering, materials engineering, chemistry, physics could take this course.

1. Organ-on-a-chip: Engineered Microenvironments for Safety and Efficacy Testing 1st Edition by Julia Hoeng, David Bovard, Manuel C. Peitsch Publisher ‏ : ‎ Academic Press; 1st edition (November 25, 2019) Language ‏ : ‎ English ISBN-10 ‏ : ‎ 0128172029 ISBN-13 ‏ : ‎ 978-0128172025 2. A guide to the organ-on-a-chip, Nature Reviews Methods Primers, volume 2, Article number: 33 (2022)

Mid. exam: 30% Practical test I : 15% Practical test II: 15% Final presentation: 30% Attendance:10%

Human Organs-on-a-Chip: Novel Organ-on-a-Chip Techniques in Medicine 1st Edition by Javier Ramón-Azcón, Artur Rydosz PhD Publisher ‏ : ‎ Academic Press; 1st edition (November 27, 2023) Language ‏ : ‎ English ISBN-10 ‏ : ‎ 0443153841 ISBN-13 ‏ : ‎ 978-0443153846

地點

實驗大樓三樓 Room Ｂ２０６

時間

Friday: 2:00-4:00 pm

聯絡方式

02-28267000 #67024