放射分子生物學
Radiation Molecular Biology
| 節 | 週三 |
|---|---|
7 15:30–16:20 | 放射分子生物學 YT103 2 節連堂 |
8 16:30–17:20 |
* 根據陽明交大上課時間表所列
Based on molecular biology, this course will introduce the impact of ionizing radiation at the molecular level of cells and mammals, including DNA replication and recombination, DNA damage and repair, gene transcription and translation, regulation of gene expression, oxidative stress, radiation molecular biotechnology, molecular Information conduction and even system biology will be introduced and discussed. The topic of interestes include: 1. Ionizing radiation can cause biological damage, including inflammation, cell death, genetic effects, and cancer. 2. The triggering mechanism of these reactions includes a series of molecular-level actions and the conduction of molecular messages. 3. Ionizing radiation also causes damage to matter and its structure at the molecular level, resulting in macroscopic biological phenomena.
Suggested pre-course: Biochemistry
To offer the knowledge about the ionizing radiation may cause biological effects at the molecular levels, such as DNA replication , repair, gene transcription and translation, and even epigenetic regulation etc.
期中考 (Midterm): 40% 期末考 (Final): 40% 出席率 (Attendence): 20%
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction of molecular biology and Radiation effects |
| 第 2 週 | Biochemical proterties of nucleic acid |
| 第 3 週 | DNA propagation |
| 第 4 週 | Radiation effects and Oxidative stress on gene regulation |
| 第 5 週 | Radiation effect on DNA – DNA damage and DNA Repair |
| 第 6 週 | Gene transcription |
| 第 7 週 | DNA recombination and gene transposition |
| 第 8 週 | Mid-term examination |
| 第 9 週 | Regulation of gene transcription |
| 第 10 週 | RNA modification, editing and silencing |
| 第 11 週 | Gene translation and Protein modification of Gene translation |
| 第 12 週 | Molecular carcinogenesis by ionizing radiation |
| 第 13 週 | Human Genome and single nucleotide polymorphisms (SNPs) |
| 第 14 週 | Principle of microarray and application and systems radiational biology |
| 第 15 週 | Current Topics |
| 第 16 週 | Final exam. |
Handouts provided by individual lecturers