細胞訊息傳導與疾病

綱要: I. 膜上受體 1. 訊息傳導介紹 2. 受體 3. G蛋白偶合受體的分類與訊息傳遞路徑 4. 酵素連結受體的分類與訊息傳遞路徑 5. 離子通道的結構與功能 I.膜上受體與疾病 6. 癌症及老化 7. 疼痛及自體免疫性疾病 8. 情緒疾病及神經性退化性疾病 Topics PART I – Introduction of membrane-bound receptors 1. Signal transduction: concept and overview 2. Receptors and First messenger 3. G-protein coupled receptors: structure, classification, and signaling pathways 4. Enzyme-coupled receptors: classification and signaling pathways 5. Ion channels: Structure and function PART II - Membrane-bound receptors and diseases: 6. Cancer and Aging 7. Pain and Rheumatology 8. Mood Disorders and Neurodegenerative Disorders 此課程主旨在介紹負責傳遞胞外多種訊息的膜上受體，包括G蛋白偶合受體、酵素連結受體與離子通道，其調控胞內反應的分子機制與疾病的關連性。由於膜上受體功能上的缺失常造成許多疾病，因此，此類型受體為極具潛力的藥物標的分子。至目前為止，超過半數的上市藥物都是藉由調控特定的膜上受體的訊息傳遞來治療疾病。課程內容包含兩部分：第一部分介紹 G蛋白偶合受體、酵素連結受體與離子通道的結構、功能與訊息傳遞路徑。第二部分將探討膜上受體與癌症、老化、自體免疫性、神經性退化性、憂鬱症、疼痛等疾病的關連性。除此之外，更包含近期科學在臨床藥理、醫學上重要研究與應用。藉由瞭解訊息傳遞分子機制配合目前臨床藥理、醫學上的研究的發展，讓學生了解膜上受體調控疾病的分子機轉，有助於學生在病理機制的基礎研究，臨床醫療發展與藥物開發與設計等應用。 This course offers a comprehensive introduction to signal transduction pathways mediated by membrane-bound receptors, which play a crucial role in responding to numerous extracellular signals. These receptors, including G-protein-coupled receptors, enzyme-linked receptors, and ion channels, are vital not only for understanding cellular responses but also for their significance in disease regulation and as promising drug targets. In fact, over 50% of all marketed medications are designed to interact with these membrane-bound receptors. The course is structured into two key sections: (I) An engaging introduction to membrane-bound receptors, covering their structures, functions, and the various signaling pathways they are involved in; (II) A thorough examination of the link between membrane-bound receptors and diseases, focusing on how these receptors influence disease mechanisms at a molecular level. Moreover, the course highlights cutting-edge applications of these receptors in the fields of pharmacology and clinical medicine, providing valuable insights into their potential to shape future therapeutic strategies.

General Biology

Lectures, presentation, and discussion

筆試/作業40% + 上課表現10% +口頭及書面報告40% 40% written exam/homework, 40% oral presentation and written report, and 10% class performance

1. Signal Transduction, 2009, 2nd edition by Gomerts, Kramer, and Tatham, Elsevier Inc. 2. Signal Transduction and human disease, 2003 by Finkel and Gutkind, A John Wiley & Sons, Inc 3. Pain Control, 2004, edited by Schaible HG 4. Published papers

地點

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時間

10:00 am, Fridays

聯絡方式

886-2-2826-7000 ext 67268