蛋白質物理生化學
Physical Biochemistry of Protein
學期
114-2
學分
3
學分
當期課號
430018
永久課號
BTBT30144
開課單位
生物科技學系
授課教師
張家靖
校區
博愛
類別
選修
上課時間表
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 蛋白質物理生化學 BI308 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
概述
使學生對蛋白質之生物物理化學機制有所認知與徹底瞭解
先修科目
建議需具備普通物理與普通化學以上之修課經驗與能力
評分方式
出席率: 20% 作業部份：30% 期末報告: 50%
課程大綱
- 1. Introduction of protein 2. Elementary interactions in and around proteins 3. Secondary structure of polypeptide chains 4. Protein structures 5. Cooperation transitions in protein molecules 6. Prediction and design of protein structure. 7. Physical background of protein functions
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction of protein:Main functions of proteins |
| 第 2 週 | Elementary interactions in and around proteinsa. Stereochemistry of L- amino acidsb. Covalent bonds and angles between themc. Vibration, rotation around the covalent bondsd. Van de Waals interaction |
| 第 3 週 | Elementary interactions in and around proteinse. Influence of water environmentf. Hydrogen bonds and their electrostatic origing. Elements of thermodynamicsh. Water-accessible surface of proteini. Influence of aqueous environment on electrostatic interactions |
| 第 4 週 | Secondary structure of polypeptide chainsa. Elementary of statistical mechanicsb. Temperature and probability of states with different energyc. The first order phase transitions |
| 第 5 週 | Secondary structure of polypeptide chains d. The theory of reaction ratese. Zipper model of alpha-helicesf. beta-structure stability in waterg. Properties of amino acid side chains |
| 第 6 週 | Protein structuresa. Fibrous proteins and their functionsb. Membrane proteins and their and their functions |
| 第 7 週 | Protein structuresc. Globular proteins and their and their functionsd. Intrinsic disorder proteins and their functions |
| 第 8 週 | Protein structurese. Classification of protein foldsf. Selection rule of protein structure |
| 第 9 週 | Cooperation transitions in protein moleculesa. Cooperative transitionsb. Protein denaturation |
| 第 10 週 | Cooperation transitions in protein moleculesc. Protein foldingd. Protein aggregation |
| 第 11 週 | Prediction and design of protein structurea. Secondary structure prediction |
| 第 12 週 | Prediction and design of protein structure b. Tertiary structure prediction |
| 第 13 週 | Physical background of protein functionsa. Structure function relationship of proteins |
| 第 14 週 | Physical background of protein functions b. Combination of elementary protein functions and flexibility of its structure |
| 第 15 週 | Special topics report, presentation and discussion |
| 第 16 週 | 期末考周 |
| 第 17 週 | 彈性授課周 |
| 第 18 週 | 彈性授課周 |
教科書
Protein physics: A course of Lectures. Authors: Alexei V Finkelstein and Oleg B Ptitsyn Academic Press 2002
Office Hours
- 地點
- 生科實驗二館203室
- 時間
- 每星期二早上9:00~12:00
- 聯絡方式
- ext 31633