質譜數據解析與生醫科技應用
Mass Spectrometry Data Analysis and Applications in Biomedicine and Biotechnology
| 節 | 週五 |
|---|---|
5 13:20–14:10 | 質譜數據解析與生醫科技應用 BI301 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
This course introduces students to the fundamental principles of mass spectrometry and its integration with modern omics technologies. Students will explore how these techniques are applied at the intersection of biomedicine and biotechnology to address complex biological questions, advance clinical applications, support drug development, and enable physiological and metabolic analysis. The course provides a comprehensive overview of how mass spectrometry can be applied to diverse biological samples and clinical specimens, highlighting its role in proteomics, PTMomics, biomarker discovery, immunology, signaling pathways, and multi-omics. In addition to lectures, students will engage in hands-on projects that involve analyzing real mass spectrometry datasets, gaining practical skills in data interpretation and application. By the end of the course, students will have developed a solid foundation in mass spectrometry analysis and will be equipped to apply these approaches in research across the fields of biomedicine and biotechnology. *** Please bring your own laptop to the course for the hand-on practice.
Basic concepts or knowledge of biochemistry, analytical chemistry, or cell biology Basic skills for using excel or programming
Lectures, PowerPoint presentation, self-edited teaching materials, discussion, and hand-on practice
Project assignment (30%) + Presentation (30%) + Final report (20%) Quizzes, class interaction, Q&A (20%)
| 週次 | 主題 |
|---|---|
| 第 1 週 | National Holiday (no class) |
| 第 2 週 | Course introduction Concept of mass spectrometry (MS)-based omics |
| 第 3 週 | Principals and technology of mass spectrometry (MS)-based omic analysis |
| 第 4 週 | (1) Biomarker discovery by shotgun proteomics (2) Project-based study and hand-on practice |
| 第 5 週 | (1) Label-free quantitative proteomics (2) Project-based study and hand-on practice |
| 第 6 週 | National Holiday (no class) |
| 第 7 週 | (1) Isobaric labeling quantitation of tissue proteomics (2) Project-based study and hand-on practice |
| 第 8 週 | (1) Quantitative phosphoproteomics (2) Project-based study and hand-on practice |
| 第 9 週 | (1) MS-based (immuno-)peptidomics (2) Project-based study and hand-on practice |
| 第 10 週 | National Holiday (no class) |
| 第 11 週 | (1) Large-scale plasma proteomics in patients (2) Project-based study and hand-on practice |
| 第 12 週 | (1) Multi-omics in patients (2) Project-based study and hand-on practice |
| 第 13 週 | Project-based study and oral presentation (1) |
| 第 14 週 | Project-based study and oral presentation (2) |
| 第 15 週 | Project-based study and oral presentation (3) (Self-study / Prof. Chen will attend an international conference) |
| 第 16 週 | Final competition – final report and independent testing |
(1) Advances in Omics Technologies: Exploring Genomics, Proteomics, and Metabolomics, eBook, 2025 (2) From Proteins to Proteomics: Basic Concepts, Techniques, and Applications (By Sanjeeva Srivastava, Published December 28, 2022 by CRC Press) (3) Mass Spectrometry Handbook (Mike S. Lee), 2012 (4) Published literature and reviews (5) Self-edited teaching materials
- 地點
- Room 520, BioICT Building, Boai Campus (博愛校區賢齊館520)
- 時間
- Arrange time by Email
- 聯絡方式
- tp7249@nycu.edu.tw