神經心臟電生理
Neural and Cardiac Electrophysiology
| 節 | 週四 |
|---|---|
2 09:00–09:50 | 神經心臟電生理 EE208 3 節連堂 |
3 10:10–11:00 | |
4 11:10–12:00 |
* 根據陽明交大上課時間表所列
The transmembrane electrical potential is a core property of all living cells and the foundation of excitability, signaling, and physiological coordination. In neurons and cardiac tissues, rapid changes in membrane potential generate action potentials that drive neural communication and regulate heart rhythm. This course introduces the biophysical mechanisms underlying ion transport, signal propagation, and electrophysiological modulation, emphasizing how these principles support modern biomedical technologies. By integrating neural and cardiac electrophysiology within an engineering perspective, students will learn to evaluate and design tools that interface with excitable tissues for sensing, stimulation, and therapeutic intervention. The course is suitable for advanced undergraduates, graduate students, and professionals in biomedical engineering, physiology, and related fields, offering interdisciplinary insights with clinical and engineering relevance. Course Goals: 1. Explain membrane electrophysiology and action potential mechanisms. 2. Analyze recording, propagation, and modulation in excitable tissues. 3. Evaluate technologies for neural and cardiac therapies. 4. Explore emerging platforms for neuromodulation and bioelectronic medicine.
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Websites and textbooks
Attendance 10%, Final 50％, Case Discussion & Reports 40％.
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to Excitable Cells and Membrane Electrophysiology (Cell membrane structure, resting potential, ionic gradients, Nernst & Goldman equations. Course overview.) |
| 第 2 週 | Ion Channels, Pumps, and Transport Mechanisms (Gating kinetics, channel conductance, patch-clamp fundamentals; channelopathies overview.) |
| 第 3 週 | Action Potentials and Signal Propagation in Neurons (Hodgkin–Huxley model, cable theory, saltatory conduction, myelination disorders.) |
| 第 4 週 | Synaptic Transmission and Network Signal Integration (Chemical vs. electrical synapses, neurotransmission steps, EPSP/IPSP, neural network circuit basics.) |
| 第 5 週 | Neural Recording Techniques and Signal Processing (Extracellular/intracellular recording, EEG, MEA, spike sorting, artifact removal, neural signal interpretation.) |
| 第 6 週 | Neural Stimulation and Modulation Technologies (Electrical stimulation, deep brain stimulation, TMS, optogenetics, vagus nerve modulation; safety and ethics.) |
| 第 7 週 | Brain–Machine Interfaces and Neuroprosthetics (Motor decoding, sensory feedback, implant biocompatibility, wearable neural interfaces. Case studies.) |
| 第 8 週 | Emerging Neuroengineering Trends (Soft neural probes, neuromorphic chips, biohybrid systems, organoids-on-chips; student mini presentations.) |
| 第 9 週 | Introduction to Cardiac Electrophysiology (Cardiac muscle physiology, pacemaker cells, conduction system, ECG fundamentals.) |
| 第 10 週 | Action Potentials in Cardiac Tissue and Arrhythmogenesis (Cardiac AP phases, ion channel diversity, reentry circuits, conduction block, fibrillation.) |
| 第 11 週 | Cardiac Signal Recording and Mapping Technologies (ECG, intracardiac recordings, electrophysiology labs, catheter mapping, imaging integration.) |
| 第 12 週 | Therapeutic Modulation: Defibrillation, Ablation & Pacing (Antiarrhythmic drugs, radiofrequency ablation, cryoablation, pacemakers, ICDs.) |
| 第 13 週 | Computational Modeling in Neural and Cardiac Systems (Hodgkin–Huxley modeling, cardiac tissue simulations, signal prediction, AI in diagnostics.) |
| 第 14 週 | Bioelectronic Medicine and Closed-Loop Therapies (Closed-loop pacemakers, neuromodulation for cardiac disease, implantable therapeutic systems.) |
| 第 15 週 | Clinical Case Discussions & Film Review Presentations by Students (Discussion of clinical cases involving arrhythmias, neuromodulation, neurological disorders.) -- Report Submission |
| 第 16 週 | An Open-Book Final Exam |
1. Introduction to Neuroengineering, Mercedes Terry, Abigail Tubbs, Blair Dupre, Brandon Fugger, and Enrique Alvarez Vazquez, Open Educational Resources. 38, Digital Publisher: University of North Dakota, 2024. DOI: 10.31356/oers038. 2. Handbook of Neural Engineering, Stephanie Willerth, Publisher: ACADEMIC Press, 2025. ISBN: 978-0-323-95730-4. 3. Cardiac Electrophysiology Methods and Models: A Practical Handbook for Scientists, Engineers, and Clinicians, Paul A. Iaizzo, Michael D. Eggen, Tinen L. Iles, Publisher: Springer, 2024. ISBN-13: 978-3-031-71066-7.
- 時間
- Tuesday 01:00 pm~03:00 pm
- 聯絡方式
- splin1@nycu.edu.tw